Gene Detail


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Gene Symbol LMNA
Synonyms CDCD1 | CDDC | CMD1A | CMT2B1 | EMD2 | FPL | FPLD | FPLD2 | HGPS | IDC | LDP1 | LFP | LGMD1B | LMN1 | LMNC | LMNL1 | MADA | PRO1
Gene Description LMNA, lamin A/C, is a component of the nuclear lamina that forms the structural framework of the nuclear envelope (PMID: 25283634) and may play a role in the response to DNA damage (PMID: 31647095). An LMNA fusion with NTRK1 has been identified in colorectal cancer (PMID: 31792356, PMID: 26563355) and congenital infantile fibrosarcoma (PMID: 26563356), and decreased Lmna expression has been associated with decreased survival in breast cancer (PMID: 30610489).
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