Gene Detail

Gene Symbol MCL1
Synonyms bcl2-L-3 | BCL2L3 | EAT | Mcl-1 | MCL1-ES | mcl1/EAT | MCL1L | MCL1S | TM
Gene Description MCL1, induced myeloid leukemia cell differentiation protein Mcl-1, is a BCL2-family member that functions in inhibition of apoptosis to promote cell survival (PMID: 29061914). MCL1 overexpression and/or amplification has been reported in a variety of tumor types (PMID: 26556430, PMID: 23478333), including NSCLC (PMID: 29567880), cholangiocarcinoma (PMID: 17404574), hepatocellular carcinoma (PMID: 16289418), melanoma (PMID: 17384650), and hematologic malignancies (PMID: 29061914).
Entrez Id 4170
Chromosome 1
Map Location 1q21.2
Canonical Transcript NM_021960

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