Gene Detail


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Gene Symbol MCL1
Synonyms bcl2-L-3 | BCL2L3 | EAT | Mcl-1 | MCL1-ES | mcl1/EAT | MCL1L | MCL1S | TM
Gene Description MCL1, MCL1 apoptosis regulator, BCL2 family member, functions in inhibition of apoptosis to promote cell survival (PMID: 29061914) and can be alternatively spliced to produce pro-apoptotic and anti-apoptotic isoforms (PMID: 32303702). MCL1 overexpression and/or amplification has been reported in a variety of tumor types (PMID: 26556430, PMID: 23478333), including NSCLC (PMID: 29567880), cholangiocarcinoma (PMID: 17404574), hepatocellular carcinoma (PMID: 16289418), melanoma (PMID: 17384650), and hematologic malignancies (PMID: 29061914) and MCL1 is often involved in adaptive resistance to targeted therapies (PMID: 31988312).
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