Gene Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, variants, or PubMed publications.

Have questions, comments or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Gene Symbol MCL1
Synonyms bcl2-L-3 | BCL2L3 | EAT | Mcl-1 | MCL1-ES | mcl1/EAT | MCL1L | MCL1S | TM
Gene Description MCL1, MCL1 apoptosis regulator, BCL2 family member, functions in inhibition of apoptosis to promote cell survival (PMID: 29061914). MCL1 overexpression and/or amplification has been reported in a variety of tumor types (PMID: 26556430, PMID: 23478333), including NSCLC (PMID: 29567880), cholangiocarcinoma (PMID: 17404574), hepatocellular carcinoma (PMID: 16289418), melanoma (PMID: 17384650), and hematologic malignancies (PMID: 29061914) and MCL1 is often involved in adaptive resistance to targeted therapies (PMID: 31988312).


Additional content available in CKB BOOST