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Gene Symbol MET
Synonyms AUTS9 | c-Met | DA11 | DFNB97 | HGFR | RCCP2
Gene Description MET, MET proto-oncogene, receptor tyrosine kinase, is a receptor tyrosine kinase, which activates MAPK, PI3K/AKT, SRC, and STAT pathways to promote cell proliferation, invasion, and angiogenesis (PMID: 22128285). MET mutations, exon 14 skipping mutations (PMID: 31369639), and fusions have been identified in a variety of human cancers (PMID: 28603720), including lung cancer (PMID: 32273721), and MET amplification and/or overexpression has been reported in many solid tumors, including biliary tract cancer (PMID: 28638453), breast cancer (PMID: 31991499, PMID: 31892551, PMID: 32234363), NSCLC (PMID: 31832192), gastric cancer (PMID: 31499745), intrahepatic cholangiocarcinoma (PMID: 32089411), and gallbladder carcinoma (PMID: 31645095).
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