Gene Detail


Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at :

Gene Symbol AFF1
Synonyms AF4 | FEL | MLLT2 | PBM1
Gene Description AFF1, AF4/FMR2 family member 1, is also referred to as AF4, and is a transcription elongation cofactor that regulates gene expression (PMID: 24367103) and plays a role in response to genotoxic stress (PMID: 31611376). AFF1 gene rearrangements with KMT2A are frequently observed in childhood leukemia (PMID: 20701601) and B-lymphoblastic leukemia (PMID: 32114371).
Additional content available in CKB BOOST