Gene Detail

Gene Symbol MSH3
Synonyms DUP | FAP4 | MRP1
Gene Description MSH3, mutS homolog 3, encodes for one of the DNA mismatch repair proteins, which forms a stable heterodimer with MSH2 in order to recognize and repair mismatched DNA (PMID: 8942985). Somatic MSH3 mutations have been identified in colon, lung, and breast cancers, and oral squamous cell carcinoma while MSH3 polymorphisms, which may be associated with increased risk, have been observed in ovarian and prostate cancers, and non-small cell lung carcinoma (PMID: 25966119).
Entrez Id 4437
Chromosome 5
Map Location 5q14.1
Canonical Transcript NM_002439

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