Gene Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Gene Symbol ASPH
Synonyms AAH | BAH | CASQ2BP1 | FDLAB | HAAH | JCTN | junctin
Gene Description ASPH, aspartate beta-hydroxylase, is a transmembrane protein that hydroxylates certain residues within EGF-domain containing proteins, including Notch and Jagged to promote cell migration (PMID: 28985022). Altered ASPH expression has been observed in hepatocellular carcinoma (PMID: 24954865), cholangiocarcinoma (PMID: 26954680), and luminal B breast cancer (PMID: 28985022), and overexpression has been observed in pancreatic cancer (PMID: 30179586, PMID: 31888763).
Additional content available in CKB BOOST