Gene Detail


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Gene Symbol ASPH
Synonyms AAH | BAH | CASQ2BP1 | FDLAB | HAAH | JCTN | junctin
Gene Description ASPH, aspartate beta-hydroxylase, is a transmembrane protein that hydroxylates certain residues within EGF-domain containing proteins, including Notch and Jagged to promote cell migration (PMID: 28985022). Altered ASPH expression has been observed in hepatocellular carcinoma (PMID: 24954865), cholangiocarcinoma (PMID: 26954680), and luminal B breast cancer (PMID: 28985022), and overexpression has been observed in pancreatic cancer (PMID: 30179586, PMID: 31888763).
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