Gene Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Gene Symbol ZFHX3
Synonyms ATBF1 | ATBT | ATFB8 | C16orf47 | SCA4 | ZFH-3 | ZNF927
Gene Description ZFHX3, zinc finger homeobox 3, encodes a transcription factor that functions as a tumor suppressor by transactivating CDKN1A and repressing AFP (PMID: 29126922, PMID: 20599712). ZFHX3 mutations and loss of heterozygosity have been identified in gastric (PMID: 17671116), prostate (PMID: 15750593), and endometrial cancer (PMID: 26330387).
Additional content available in CKB BOOST