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Gene Symbol NF2
Synonyms ACN | BANF | SCH
Gene Description NF2, neurofibromin 2, is a tumor suppressor that inhibits cell proliferation and promotes apoptosis through regulating cell-cell contact and gene expression (PMID: 22482125). Germline inactivating mutations of NF2 cause neurofibromatosis 2, while somatic mutations of NF2 are identified in a wide variety of tumors (PMID: 24393766), including vestibular schwannoma (PMID: 31789805) and malignant mesothelioma (PMID: 29656754).


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