Gene Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, variants, or PubMed publications.

Have questions, comments or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Gene Symbol NFE2
Synonyms NF-E2 | p45
Gene Description NFE2, nuclear factor, erythroid 2, is a transcription factor that is involved in the regulation of heme and globin genes (PMID: 9675875), playing a key role in megakaryocyte and erythroid differentiation and maturation and the formation of platelets (PMID: 24951464, PMID: 11012210, PMID: 17923245). NFE2 mutations have been identified in myeloid sarcoma (PMID: 29191917) and NFE2 overexpression and activating mutations have been associated with myeloproliferative neoplasms (PMID: 23589569).
Additional content available in CKB BOOST