Gene Detail

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Gene Symbol NRAS
Synonyms ALPS4 | CMNS | KRAS | N-ras | NCMS | NRAS1 | NS6
Gene Description NRAS, NRAS proto-oncogene, GTPase, is a member of the family of small GTPase that when activated by growth factors, stimulates multiple effector pathways such as RAF and PI3K to promote cell proliferation and survival (PMID: 29524560). NRAS mutations have been observed in a variety of cancers including melanoma, thyroid, breast, ovary cancer, and leukemia (PMID: 29524560, PMID: 30154648, PMID: 28860801).

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Molecular Profile Protein Effect Treatment Approaches
NRAS A11T unknown
NRAS A146T gain of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan)
BRAF V600E MAP2K1 P387S NRAS A146T
BRAF V600E NRAS A146T
BRAF V600E MAP2K1 P387S NRAS Q61K NRAS A146T
BRAF V600E NRAS Q61K NRAS A146T
NRAS A146V gain of function - predicted
NRAS A146X unknown
NRAS A18T no effect - predicted
NRAS A59X unknown
NRAS A66V unknown
NRAS act mut unknown
CDKN2A mut NRAS act mut
FGFR3 rearrange NRAS act mut
NRAS amp no effect
FGFR1 amp NRAS amp
BRAF V600E NRAS amp
NRAS D154G unknown
NRAS D154H unknown
NRAS D175N unknown
NRAS D54N unknown
NRAS D57A unknown
BRAF V600D NRAS dec exp
NRAS dec exp no effect
NRAS E132K loss of function - predicted
NRAS E162* loss of function - predicted
NRAS E63K loss of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan)
NRAS exon2 unknown
NRAS exon3 unknown
NRAS exon4 unknown
NRAS G115Efs*46 loss of function - predicted
NRAS G12A loss of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan)
NRAS G12C loss of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan)
NRAS G12D loss of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan)
KMT2A - MLLT1 NRAS G12D
BRAF D594G NRAS G12D
DNMT3A R882H NRAS G12D
FLT3 exon 14 ins NRAS G12D
KMT2A - MLLT3 NRAS G12D
NRAS G12N loss of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan)
NRAS G12P loss of function - predicted
NRAS G12R loss of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan)
NRAS G12S loss of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan)
NRAS G12V loss of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan)
BRAF V600E NRAS G12V
FGFR2 - PPHLN1 NRAS G12V
BRAF V600E CDKN2A loss NRAS G12V
NRAS G12X unknown MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan)
NRAS G12Y loss of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan)
NRAS G13A unknown MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan)
NRAS G13C loss of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan)
NRAS G13D loss of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan)
NRAS G13R loss of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan)
BRAF G596V NRAS G13R
BRAF V600E NRAS G13R
NRAS G13S gain of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan)
NRAS G13V loss of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan)
NRAS G13X unknown MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan)
NRAS G60E loss of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan)
NRAS G60R loss of function - predicted
NRAS H131R unknown
NRAS I24L unknown
NRAS I24N loss of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan)
NRAS inact mut loss of function
NRAS K117X unknown
NRAS K135N no effect
NRAS mutant unknown
BRAF wild-type NRAS mut
CDKN2A loss NRAS mut
BRAF mut NRAS mut
CTNNB1 mut NRAS mut
NRAS mut PIK3CA wild-type
NRAS mut PIK3CA H1047R
NRAS mut PIK3CA E545K
NRAS Q61L NRAS mut
NRAS Q61K NRAS mut
NRAS mut TP53 wild-type
NRAS mut TP53 mut
NRAS over exp no effect
FGFR1 amp NRAS over exp
BRAF V600E NRAS over exp
NRAS P34A unknown
NRAS P34L loss of function - predicted
NRAS positive unknown
NRAS Q129E unknown
NRAS Q150H unknown
NRAS Q22K unknown
NRAS Q61E loss of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan)
NRAS Q61H loss of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan)
NRAS Q61K loss of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan)
BRAF V600E NRAS Q61K
CDKN2A loss NRAS Q61K
BRAF V600E MAP2K1 P387S NRAS Q61K
BRAF V600K NRAS Q61K
BRAF G469R NRAS Q61K
BRAF V600X BRAF amp NRAS Q61K
BRAF wild-type NRAS Q61K
BRAF L597V NRAS Q61K
BRAF G466V NRAS Q61K
BRAF G596R NRAS Q61K
BRAF G469V NRAS Q61K
ATM T1200Lfs*7 NRAS Q61K TP53 R213*
BRAF D287H NRAS Q61K
BRAF loss NRAS Q61K
BRAF L597Q FGFR2 H167_N173del FGFR2 N550K FGFR2 L618F NRAS Q61K
BRAF V600E CDKN2A loss NRAS Q61K
NRAS Q61L loss of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan)
BRAF G534D NRAS Q61L
BRAF V600E NRAS Q61L
NRAS Q61P loss of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan)
NRAS Q61R loss of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan)
BRAF V600X MAP2K1 V60E NRAS T58I NRAS Q61R
KIT D816V NRAS Q61R
ATM mut NRAS Q61R
BRAF V600E MAP2K1 Q56P NRAS Q61R
NRAS Q61X unknown MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan)
NRAS R164C no effect - predicted
NRAS R167L unknown
NRAS S106L unknown
NRAS S65C loss of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan)
NRAS S65G unknown
NRAS S89A loss of function
NRAS S89D unknown
NRAS T50I gain of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan)
NRAS T58I loss of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan)
NRAS T58_A59insTDV unknown
NRAS T74S unknown
NRAS wild-type no effect
BRAF mut NRAS wild-type
BRAF wild-type NRAS wild-type
NRAS Y40* loss of function - predicted
NRAS Y64D loss of function - predicted