Gene Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, variants, or PubMed publications.

Have questions, comments or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Gene Symbol NRAS
Synonyms ALPS4 | CMNS | N-ras | NCMS | NRAS1 | NS6
Gene Description NRAS, NRAS proto-oncogene, GTPase, is a member of the family of small GTPase that when activated by growth factors, stimulates multiple effector pathways such as RAF and PI3K to promote cell proliferation and survival (PMID: 29524560). NRAS mutations have been observed in a variety of cancers including melanoma, thyroid, breast, ovary cancer, and leukemia (PMID: 29524560, PMID: 30154648, PMID: 28860801).

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Molecular Profile Protein Effect Treatment Approaches
NRAS A11T unknown
NRAS A146T gain of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan)
BRAF V600E MAP2K1 P387S NRAS A146T
BRAF V600E NRAS A146T
BRAF V600E MAP2K1 P387S NRAS Q61K NRAS A146T
BRAF V600E NRAS Q61K NRAS A146T
NRAS A146V gain of function - predicted
NRAS A146X unknown
NRAS A18T unknown
NRAS A59X unknown
NRAS A66V unknown
NRAS act mut unknown
CDKN2A mut NRAS act mut
NRAS amp no effect
FGFR1 amp NRAS amp
BRAF V600E NRAS amp
NRAS D154G unknown
NRAS D154H unknown
NRAS D175N unknown
NRAS D54N unknown
NRAS D57A unknown
BRAF V600D NRAS dec exp
NRAS dec exp no effect
NRAS E132K loss of function - predicted
NRAS E162* loss of function - predicted
NRAS E63K loss of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan)
NRAS exon2 unknown
NRAS exon3 unknown
NRAS exon4 unknown
NRAS G12A loss of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan)
NRAS G12C loss of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan)
NRAS G12D loss of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan)
KMT2A - MLLT1 NRAS G12D
BRAF D594G NRAS G12D
AKT1 E17K NRAS G12D
DNMT3A R882H NRAS G12D
NRAS G12N loss of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan)
NRAS G12P loss of function - predicted
NRAS G12R loss of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan)
NRAS G12S loss of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan)
NRAS G12V loss of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan)
BRAF V600E NRAS G12V
NRAS G12X unknown MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan)
NRAS G12Y loss of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan)
NRAS G13A unknown MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan)
NRAS G13C loss of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan)
NRAS G13D loss of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan)
NRAS G13R loss of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan)
BRAF G596V NRAS G13R
BRAF V600E NRAS G13R
NRAS G13S loss of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan)
NRAS G13V loss of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan)
NRAS G13X unknown MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan)
NRAS G60E loss of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan)
NRAS G60R unknown
NRAS H131R unknown
NRAS I24L unknown
NRAS inact mut loss of function
NRAS K117X unknown
NRAS K135N no effect - predicted
NRAS mutant unknown
BRAF wild-type NRAS mut
CDKN2A loss NRAS mut
BRAF mut NRAS mut
CTNNB1 mut NRAS mut
NRAS mut STAG2 dec exp
NRAS mut PIK3CA wild-type
AKT1 pos NRAS mut
NRAS mut PIK3CA H1047R
NRAS mut PIK3CA E545K
NRAS Q61L NRAS mut
NRAS Q61K NRAS mut
NRAS over exp no effect
FGFR1 amp NRAS over exp
BRAF V600E NRAS over exp
NRAS P34A unknown
NRAS P34L loss of function - predicted
NRAS positive unknown
NRAS Q129E unknown
NRAS Q150H unknown
NRAS Q22K unknown
NRAS Q61E loss of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan)
NRAS Q61H loss of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan)
NRAS Q61K loss of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan)
BRAF V600E NRAS Q61K
CDKN2A loss NRAS Q61K
BRAF V600E MAP2K1 P387S NRAS Q61K
BRAF V600K NRAS Q61K
BRAF G469R NRAS Q61K
BRAF V600X BRAF amp NRAS Q61K
BRAF wild-type NRAS Q61K
BRAF L597V NRAS Q61K
BRAF G466V NRAS Q61K
BRAF G596R NRAS Q61K
BRAF G469V NRAS Q61K
NRAS Q61L loss of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan)
NRAS Q61P loss of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan)
NRAS Q61R loss of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan)
AKT1 E17K NRAS Q61R
BRAF V600X MAP2K1 V60E NRAS T58I NRAS Q61R
KIT D816V NRAS Q61R
ATM mut NRAS Q61R
NRAS Q61X unknown MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan)
NRAS R164C unknown
NRAS R167L unknown
NRAS S106L unknown
NRAS S65C loss of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan)
NRAS S65G unknown
NRAS S89A loss of function
NRAS S89D unknown
NRAS T50I gain of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan)
NRAS T58I loss of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan)
NRAS T58_A59insTDV unknown
NRAS T74S unknown
NRAS wild-type no effect
BRAF mut NRAS wild-type
BRAF wild-type NRAS wild-type
ERBB2 amp NRAS wild-type
BRAF wild-type ERBB2 amp NRAS wild-type
NRAS Y40* loss of function - predicted
NRAS Y64D unknown