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|Synonyms||MTC | p140-TrkA | TRK | Trk-A | TRK1 | TRKA|
|Gene Description||NTRK1, neurotrophic receptor tyrosine kinase 1, is a receptor tyrosine kinase involved in maturation and development of the nervous system through MAPK/ERK and AKT/PKB signaling pathways (PMID: 30542115). Fusions involving NTRK1, with multiple gene partners, and producing constitutively active Ntrk1 kinase activity have been demonstrated to be oncogenic in a variety of tumor types (PMID: 25054037), including pediatric cancers (PMID: 31965543) and other solid tumors (PMID: 31145161, PMID: 32127185, PMID: 32133433), while NTRK1 missense mutations are often associated with resistance to TRK inhibition (PMID: 31406350).|