Gene Detail

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Gene Symbol DDR2
Synonyms MIG20a | NTRKR3 | TKT | TYRO10 | WRCN
Gene Description DDR2, discoidin domain receptor tyrosine kinase 2, is a tyrosine kinase receptor activated by collagen, promoting cell migration, proliferation, and survival (PMID: 22328973, PMID: 27398168). Altered expression and mutations of DDR2 have been identified in a variety of solid tumors, including ovarian (PMID: 27398168), lung (PMID: 28161936), gastric (PMID: 27350126), and HNSCC (PMID: 27434411).

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Molecular Profile Protein Effect Treatment Approaches
DDR2 A21G unknown
DDR2 A695D unknown
DDR2 act mut gain of function DDR2 inhibitor
DDR2 amp no effect
EML4 - ALK DDR2 amp
DDR2 C177F unknown
DDR2 C580Y unknown
DDR2 C784_P788dup unknown
DDR2 D241Y unknown
DDR2 D613N unknown
DDR2 D648_Y656dup unknown
DDR2 D661Y unknown
DDR2 E113K loss of function - predicted
DDR2 E181K unknown
DDR2 E625K unknown
DDR2 E655K no effect
DDR2 E66G unknown
DDR2 E85* loss of function - predicted
DDR2 G126D unknown
DDR2 G253C gain of function - predicted DDR2 inhibitor
DDR2 G466R unknown
DDR2 G505S gain of function - predicted DDR2 inhibitor
DDR2 G575R unknown
DDR2 G660E unknown
DDR2 G774E unknown
DDR2 G774V gain of function - predicted DDR2 inhibitor
DDR2 H246R no effect
DDR2 H249Q unknown
DDR2 I159T unknown
DDR2 I638F DDR2 T654M
DDR2 I638F gain of function DDR2 inhibitor
DDR2 I653_M657dup unknown
DDR2 I726R loss of function
DDR2 inact mut loss of function
DDR2 K608M loss of function - predicted
DDR2 L239R gain of function - predicted DDR2 inhibitor
DDR2 L239R DDR2 T654M
DDR2 L239R DDR2 T654I
DDR2 L595P gain of function DDR2 inhibitor
DDR2 L610P gain of function - predicted DDR2 inhibitor
DDR2 L63V gain of function DDR2 inhibitor
DDR2 M117I unknown
DDR2 M441I unknown
DDR2 mutant unknown
DDR2 N134K unknown
DDR2 over exp no effect DDR2 inhibitor
DDR2 P168_S173dup unknown
DDR2 P476S unknown
DDR2 P492S unknown
DDR2 P840S unknown
DDR2 Q808H unknown
DDR2 R135H unknown
DDR2 R489fs loss of function - predicted
DDR2 R611* loss of function - predicted
DDR2 R619S unknown
DDR2 R62M unknown
DDR2 R709* unknown
DDR2 R752C loss of function
DDR2 R752H unknown
DDR2 R839H unknown
DDR2 S123I unknown
DDR2 S50N unknown
DDR2 S768R gain of function DDR2 inhibitor
DDR2 T654I unknown
DDR2 T654M unknown
DDR2 T713I loss of function
DDR2 T765P unknown
DDR2 V302I unknown
DDR2 V582E gain of function DDR2 inhibitor
DDR2 V605M unknown
DDR2 W72L unknown
DDR2 wild-type no effect
DDR2 Y122C unknown
DDR2 Y740C gain of function - predicted DDR2 inhibitor