Missing content? – Request curation!
Request curation for specific Genes, variants, or PubMed publications.
Have questions, comments or suggestions? - Let us know!
Email us at : firstname.lastname@example.org
|Synonyms||PAI | PAI-1 | PAI1 | PLANH1|
|Gene Description||SERPINE1, serpin family E member 1, encodes a serine protease inhibitor that blocks plasminogen activation, inhibits fibrinolysis (PMID: 20626406), and plays a role in inflammation (PMID: 22360729), wound repair (PMID: 24669362, PMID: 15174100), and carcinogenesis (PMID: 31734763). Increased Serpine1 expression has been identified in colorectal cancer (PMID: 22198637), melanoma (PMID: 22716255), gastric tumor (PMID: 30410354), and a fusion with FOSB has been identified in pseudomyogenic haemangioendothelioma (PMID: 28622428).|