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Gene Symbol PDE4D
Synonyms ACRDYS2 | DPDE3 | HSPDE4D | PDE43 | PDE4DN2 | STRK1
Gene Description PDE4D, phosphodiesterase 4D, is a cyclic nucleotide phosphodiesterase that regulates cAMP degradation (PMID: 16968949). Overexpression of Pde4d has been observed in a variety of cancers (PMID: 23536305), including pancreatic ductal carcinoma (PMID: 31772658) and melanoma (PMID: 28092671), decreased Pde4d expression has been demonstrated in bladder cancer (PMID: 30482227), and a PDE4D-CCNB1 fusion has been identified in ovarian endometrioid ovarian carcinoma (PMID: 29633253).
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