Gene Detail


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Gene Symbol PDGFRB
Synonyms CD140B | IBGC4 | IMF1 | JTK12 | KOGS | PDGFR | PDGFR-1 | PDGFR1 | PENTT
Gene Description PDGFRB, platelet derived growth factor receptor beta, is a receptor tyrosine kinase that plays a role in blood vessel development, cell proliferation, migration (PMID: 18483217, PMID: 20529858), and lymphangiogenesis (PMID: 31949689). PDGFRB fusions are associated with several tumor types (PMID: 24703957) and commonly found in myeloid neoplasms (PMID: 31999327, PMID: 31161074), while overexpression has been observed in metastatic non-small cell lung cancer (PMID: 31949689, PMID: 31308421) and somatic mutations in myofibroma (PMID: 31017643).
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