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|Synonyms||JBTS32 | PRO1280 | SUFUH | SUFUXL|
|Gene Description||SUFU, SUFU negative regulator of hedgehog signaling, negatively regulates hedgehog signaling via association with Gli proteins, resulting in inactivity of Gli and thereby, preventing its transcriptional activity (PMID: 20360384). SUFU loss has been associated with medulloblastoma and rhabdomyosarcoma (PMID: 27234298), and somatic SUFU mutations have been identified in prostate cancer (PMID: 15482598).|