Gene Detail

Gene Symbol SUFU
Synonyms JBTS32 | PRO1280 | SUFUH | SUFUXL
Gene Description SUFU, SUFU negative regulator of hedgehog signaling, negatively regulates hedgehog signaling via association with Gli proteins, resulting in inactivity of Gli and thereby, preventing its transcriptional activity (PMID: 20360384). SUFU loss has been associated with medulloblastoma and rhabdomyosarcoma (PMID: 27234298), and somatic SUFU mutations have been identified in prostate cancer (PMID: 15482598).
Entrez Id 51684
Chromosome 10
Map Location 10q24.32
Canonical Transcript NM_016169

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