Gene Detail

Gene Symbol CDK12
Synonyms CRK7 | CRKR | CRKRS
Gene Description CDK12, cyclin-dependent kinase 12, is a key regulator of transcription elongation, regulates the expression of genes involved in DNA repair, and is required for the maintenance of genomic stability (PMID: 24554720; PMID: 22012619). Loss and or inactivation of CDK12 has been commonly observed in many solid tumor types, including prostate (PMID: 29906450), breast, ovarian, endometrial, uterine (PMID: 30104286) and is a likely tumor suppressor (PMID: 30319007).
Entrez Id 51755
Chromosome 17
Map Location 17q12
Canonical Transcript NM_016507


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