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Clinical Trial	Phase	Therapies	Title	Recruitment Status	Covered Countries	Other Countries
NCT05455619	Phase Ib/II	Alpelisib + Fulvestrant + SDX-7320	Evexomostat Plus Alpelisib and Fulvestrant in Women With the PIK3CA Mutation With HR+/Her2- Breast Cancer (Amelia-1)	Recruiting	USA	0
NCT02925234	Phase II	Palbociclib Ribociclib Lenvatinib Ipilimumab + Nivolumab Trametinib Crizotinib Niraparib Selpercatinib Olaparib Erlotinib Erdafitinib Dabrafenib Dacomitinib Rucaparib Axitinib Panitumumab Pemigatinib Durvalumab Afatinib Entrectinib Tepotinib Alpelisib Atezolizumab + Bevacizumab Alectinib Regorafenib Cobimetinib + Vemurafenib Nilotinib Vismodegib Abemaciclib Sunitinib Nivolumab Cabozantinib Lorlatinib Talazoparib Dabrafenib + Trametinib Pembrolizumab Pertuzumab + Trastuzumab	The Drug Rediscovery Protocol (DRUP Trial) (DRUP)	Recruiting	NLD	0
NCT01219699	Phase I	Alpelisib Alpelisib + Fulvestrant	A Study of BYL719 in Adult Patients With Advanced Solid Malignancies, Whose Tumors Have an Alteration of the PIK3CA Gene	Completed	USA \| NLD \| GBR \| ESP \| DEU	0
NCT05843253	Phase II	Everolimus + Ribociclib	Study of Ribociclib and Everolimus in HGG and DIPG	Not yet recruiting	USA \| NLD \| GBR \| DEU \| CAN \| AUS	0
NCT03065062	Phase I	Gedatolisib + Palbociclib	Study of the CDK4/6 Inhibitor Palbociclib (PD-0332991) in Combination With the PI3K/mTOR Inhibitor Gedatolisib (PF-05212384) for Patients With Advanced Squamous Cell Lung, Pancreatic, Head & Neck and Other Solid Tumors	Recruiting	USA	0
NCT02189174	Phase Ib/II	CLR457	Study of CLR457 Administered Orally in Adult Patients With Advanced Solid Malignancies	Terminated	USA \| ESP \| CAN	2
NCT05683418	Phase I	TOS-358	A Study to Evaluate the Safety and Tolerability of TOS-358 in Adults With Select Solid Tumors	Recruiting	USA	0
NCT01708161	Phase I	Alpelisib + Ganitumab	A Phase Ib/II Study of the Combination of BYL719 Plus AMG 479 in Adult Patients With Selected Solid Tumors	Terminated	USA \| ESP \| CAN \| BEL	0
NCT01306045	Phase II	Erlotinib Lapatinib MK2206 Sunitinib Selumetinib	Molecular Profiling and Targeted Therapy for Advanced Non-Small Cell Lung Cancer, Small Cell Lung Cancer, and Thymic Malignancies	Active, not recruiting	USA	0
NCT01396408	Phase II	Temsirolimus Sunitinib	A Phase II Study of Sunitinib or Temsirolimus in Patients With Advanced Rare Tumours	Active, not recruiting	CAN	0
NCT04997902	Phase Ib/II	Alpelisib + Tipifarnib	Combination Trial of Tipifarnib and Alpelisib in Adult Recurrent/ Metastatic Head and Neck Squamous Cell Carcinoma (R/M HNSCC)	Recruiting	USA	0
NCT05154487	Phase II	Alpelisib + Fulvestrant	A Study of Alpelisib and Fulvestrant to Treat Endometrial Cancer	Recruiting	USA	0
NCT04762979	Phase II	Alpelisib + Fulvestrant	Alpelisib (BYL719) in Combination With Continued Endocrine Therapy Following Progression on Endocrine Therapy in Hormone Receptor Positive, HER2 Negative, PIK3CA Mutant Metastatic Breast Cancer	Recruiting	USA	0
NCT02167854	Phase I	Alpelisib + Elgemtumab + Trastuzumab	Open-Label Study Evaluating the Safety and Tolerability of LJM716, BYL719 and Trastuzumab in Patients With Metastatic HER2+ Breast Cancer	Completed	USA	0
NCT02644122	Phase II	SF1126	SF1126 in Recurrent or Progressive SCCHN and Mutations in PIK3CA Gene and/or PI-3 Kinase Pathway Genes	Terminated	USA	0
NCT04774952	Phase I	RMC-5552	Dose Escalation of RMC-5552 Monotherapy in Relapsed/Refractory Solid Tumors	Active, not recruiting	USA	0
NCT05063786	Phase III	Alpelisib + Fulvestrant + Trastuzumab Trastuzumab + Vinorelbine Alpelisib + Trastuzumab Capecitabine + Trastuzumab Eribulin + Trastuzumab	Trastuzumab + Alpelisib +/- Fulvestrant vs Trastuzumab + CT in Patients With PIK3CA Mutated Previously Treated HER2+ Advanced BrEasT Cancer (ALPHABET) (ALPHABET)	Active, not recruiting	NLD \| ITA \| FRA \| ESP \| AUT	1
NCT04300790	Phase II	Alpelisib + Fulvestrant + Metformin	Study to Evaluate the Effect of Metformin in the Prevention of HG in HR[+]/HER2[-] PIK3CA-mut Advanced BC Patients (METALLICA)	Recruiting	ESP	0
NCT05304962	Phase I	RGT-419B	First-in-Human Study of RGT-419B Alone and With Endocrine Therapy in Subjects With HR-Positive, HER2-Negative Advanced/Metastatic Breast Cancer	Recruiting	USA	0
NCT02861300	Phase Ib/II	Capecitabine + Telaglenastat	CB-839 + Capecitabine in Solid Tumors and Fluoropyrimidine Resistant PIK3CA Mutant Colorectal Cancer	Active, not recruiting	USA	0
NCT05216432	Phase I	RLY-2608 Fulvestrant + RLY-2608	First-in-Human Study of Mutant-selective PI3Kalpha Inhibitor, RLY-2608, as a Single Agent in Advanced Solid Tumor Patients and in Combination With Fulvestrant in Patients With Advanced Breast Cancer	Recruiting	USA \| ITA \| FRA \| ESP	0
NCT02728258	Phase II	Copanlisib	Copanlisib in Treating Patients With Persistent or Recurrent Endometrial Cancer	Completed	USA	0
NCT02646319	Phase I	Nab-rapamycin	Nanoparticle Albumin-Bound Rapamycin in Treating Patients With Advanced Cancer With mTOR Mutations	Completed	USA	0
NCT04916236	Phase I	LY3214996 + RMC-4630	Combination Therapy of RMC-4630 and LY3214996 in Metastatic KRAS Mutant Cancers (SHERPA)	Recruiting	NLD	0
NCT04191499	Phase II	Fulvestrant + Palbociclib Fulvestrant + Inavolisib + Palbociclib	A Study Evaluating the Efficacy and Safety of Inavolisib + Palbociclib + Fulvestrant vs Placebo + Palbociclib + Fulvestrant in Patients With PIK3CA-Mutant, Hormone Receptor-Positive, Her2-Negative, Locally Advanced or Metastatic Breast Cancer (INAVO120)	Active, not recruiting	USA \| NZL \| ITA \| GBR \| FRA \| ESP \| DEU \| CAN \| BEL \| AUS	18
NCT05038735	Phase III	Alpelisib + Fulvestrant Fulvestrant	Study to Assess the Efficacy and Safety of Alpelisib Plus Fulvestrant in Participants With HR-postitive (HR+), HER2-negative, Advanced Breast Cancer After Treatment With a CDK4/6 Inhibitor and an Aromatase Inhibitor. (EPIK-B5)	Recruiting	ITA \| FRA \| ESP \| DEU \| CAN \| BEL	11
NCT01437566	Phase II	Apitolisib Fulvestrant Pictilisib	Study of GDC-0941 or GDC-0980 With Fulvestrant Versus Fulvestrant in Advanced or Metastatic Breast Cancer in Patients Resistant to Aromatase Inhibitor Therapy	Completed	USA \| NZL \| ITA \| GBR \| FRA \| ESP \| DEU \| CAN \| BEL \| AUS	13
NCT04899349	Phase II	Alpelisib + Fulvestrant + Metformin Alpelisib + Dapagliflozin + Fulvestrant + Metformin	Study of Safety and Efficacy of Dapagliflozin + Metformin XR Versus Metformin XR in Participants With HR+, HER2-, Advanced Breast Cancer While on Treatment With Alpelisib and Fulvestrant (EPIK-B4)	Terminated	USA	1
NCT02987959	Phase II	Sapanisertib	Study of TAK-228 (MLN0128) in Soft Tissue Sarcomas	Terminated	USA	0
NCT05894239	Phase III	Inavolisib + Pertuzumab/trastuzumab/hyaluronidase-zzxf Pertuzumab/trastuzumab/hyaluronidase-zzxf	A Study to Evaluate the Efficacy and Safety of Inavolisib in Combination With Phesgo Versus Placebo in Combination With Phesgo in Participants With PIK3CA-Mutated HER2-Positive Locally Advanced or Metastatic Breast Cancer	Recruiting	USA \| ITA \| GBR \| ESP \| DEU \| CAN \| BEL \| AUS	12
NCT03337724	Phase II	Ipatasertib + Paclitaxel Paclitaxel	A Study of Ipatasertib in Combination With Paclitaxel as a Treatment for Participants With PIK3CA/AKT1/PTEN-Altered, Locally Advanced or Metastatic, Triple-Negative Breast Cancer or Hormone Receptor-Positive, HER2-Negative Breast Cancer (IPATunity130)	Completed	USA \| ITA \| GBR \| FRA \| ESP \| DEU \| CAN \| BEL \| AUS	21
NCT05773326	Phase I	Temsirolimus	Superselective Intra-arterial Cerebral Infusion of Temsirolimus in HGG	Recruiting	USA	0
NCT05563220	Phase Ib/II	Alpelisib + Elacestrant Elacestrant + Ribociclib Elacestrant + Everolimus Elacestrant + Palbociclib Abemaciclib + Elacestrant	Open-Label Umbrella Study To Evaluate Safety And Efficacy Of Elacestrant In Various Combination In Patients With Metastatic Breast Cancer (ELEVATE)	Recruiting	USA	0
NCT03834740	Phase I	Everolimus + Ribociclib	A Phase 0 /II Study of Ribociclib (LEE011) in Combination With Everolimus in Preoperative Recurrent High-Grade Glioma Patients Scheduled for Resection	Completed	USA	0
NCT03767335	Phase I	Fulvestrant + MEN1611 + Trastuzumab MEN1611 + Trastuzumab	MEN1611 With Trastuzumab (+/- Fulvestrant) in Metastatic Breast Cancer (B-PRECISE-01)	Active, not recruiting	USA \| ITA \| GBR \| FRA \| ESP \| BEL	0
NCT04208178	Phase III	Pertuzumab + Trastuzumab Alpelisib + Pertuzumab + Trastuzumab	Study of Alpelisib (BYL719) in Combination With Trastuzumab and Pertuzumab as Maintenance Therapy in Patients With HER2-positive Advanced Breast Cancer With a PIK3CA Mutation (EPIK-B2)	Active, not recruiting	USA \| ITA \| FRA \| ESP \| BEL	3
NCT00770263	Phase I	Erlotinib + Temsirolimus	Erlotinib and Temsirolimus for Solid Tumors	Completed	USA	0
NCT01226316	Phase I	Capivasertib	Safety, Tolerability & Potential Anti-cancer Activity of Increasing Doses of AZD5363 in Different Treatment Schedules	Active, not recruiting	USA \| NLD \| ITA \| GBR \| FRA \| ESP \| CAN	3
NCT05356897	Phase II	Trastuzumab + Trifluridine-tipiracil hydrochloride + Tucatinib	Tucatinib Combined With Trastuzumab and TAS-102 for the Treatment of HER2 Positive Metastatic Colorectal Cancer in Molecularly Selected Patients, 3T Study	Not yet recruiting	USA	0
NCT03297606	Phase II	Bosutinib Palbociclib Vismodegib Ipilimumab + Nivolumab Cobimetinib + Vemurafenib Temsirolimus Olaparib Erlotinib Crizotinib Sunitinib Afatinib Dasatinib Pertuzumab + Trastuzumab Axitinib	Canadian Profiling and Targeted Agent Utilization Trial (CAPTUR) (CAPTUR)	Recruiting	CAN	0
NCT05768139	Phase Ib/II	Fulvestrant + STX-478 STX-478	First-in-Human Study of STX-478 as Monotherapy and in Combination With Other Antineoplastic Agents in Participants With Advanced Solid Tumors	Recruiting	USA \| ESP	0
NCT02124148	Phase I	Cisplatin + Prexasertib Cetuximab + Prexasertib Pemetrexed Disodium + Prexasertib LY3023414 + Prexasertib Fluorouracil + Leucovorin + Prexasertib	A Study of Prexasertib (LY2606368) With Chemotherapy or Targeted Agents in Participants With Advanced Cancer	Completed	USA	0
NCT01791478	Phase I	Alpelisib + Letrozole	BYL719 and Letrozole in Post-Menopausal Patients With Hormone Receptor-Positive Metastatic Breast Cancer	Active, not recruiting	USA	0
NCT05646862	Phase III	Alpelisib + Fulvestrant Fulvestrant + Inavolisib	A Study Evaluating the Efficacy and Safety of Inavolisib Plus Fulvestrant Compared With Alpelisib Plus Fulvestrant in Participants With HR-Positive, HER2-Negative, PIK3CA Mutated, Locally Advanced or Metastatic Breast Cancer Post CDK4/6i and Endocrine Combination Therapy (INAVO121)	Recruiting	USA \| GBR \| ESP \| CAN \| BEL \| AUS	9
NCT03056755	Phase II	Alpelisib + Fulvestrant Alpelisib + Letrozole	Study Assessing the Efficacy and Safety of Alpelisib Plus Fulvestrant or Letrozole, Based on Prior Endocrine Therapy, in Patients With PIK3CA Mutant, HR+, HER2- Advanced Breast Cancer Who Have Progressed on or After Prior Treatments (BYLieve)	Active, not recruiting	USA \| NLD \| ITA \| GBR \| FRA \| ESP \| DEU \| CAN \| BEL	10
NCT02523014	Phase II	Abemaciclib GSK2256098 Vismodegib Capivasertib	Vismodegib, FAK Inhibitor GSK2256098, Capivasertib, and Abemaciclib in Treating Patients With Progressive Meningiomas	Recruiting	USA	0
NCT01928459	Phase I	Alpelisib + Infigratinib	Phase 1b Trial of BGJ398/BYL719 in Solid Tumors	Completed	USA \| NLD \| ITA \| FRA \| ESP \| DEU \| CAN \| BEL \| AUS	3
NCT03218826	Phase I	AZD8186 + Docetaxel	PI3Kbeta Inhibitor AZD8186 and Docetaxel in Treating Patients Advanced Solid Tumors With PTEN or PIK3CB Mutations That Are Metastatic or Cannot Be Removed by Surgery	Active, not recruiting	USA	0
NCT04251533	Phase III	Alpelisib + Nab-paclitaxel Nab-paclitaxel	Study Assessing the Efficacy and Safety of Alpelisib + Nab-paclitaxel in Subjects With Advanced TNBC Who Carry Either a PIK3CA Mutation or Have PTEN Loss (EPIK-B3)	Active, not recruiting	USA \| ITA \| GBR \| FRA \| ESP \| DEU \| AUT \| AUS	22
NCT04495621	Phase Ib/II	Cetuximab + MEN1611	MEN1611 With Cetuximab in Metastatic Colorectal Cancer (C-PRECISE-01) (C-PRECISE-01)	Active, not recruiting	USA \| NLD \| ITA \| FRA \| ESP \| DEU	1
NCT03006172	Phase I	Inavolisib + Letrozole + Palbociclib Inavolisib Fulvestrant + Inavolisib Inavolisib + Letrozole	To Evaluate the Safety, Tolerability, and Pharmacokinetics of Inavolisib Single Agent in Participants With Solid Tumors and in Combination With Endocrine and Targeted Therapies in Participants With Breast Cancer	Active, not recruiting	USA \| GBR \| FRA \| ESP \| CAN	0
NCT02315625	Phase II	Everolimus Sunitinib	Study of Mutation-Targeted Therapy With Sunitinib or Everolimus in People With Advanced Low- or Intermediate-Grade Neuroendocrine Tumors of the Gastrointestinal Tract and Pancreas With or Without Cytoreductive Surgery	Terminated	USA	0
NCT02576444	Phase II	Adavosertib + Olaparib Olaparib Capivasertib + Olaparib Ceralasertib + Olaparib	OLAParib COmbinations (OLAPCO)	Terminated	USA	0
NCT02340221	Phase III	Fulvestrant + Taselisib Fulvestrant	A Study of Taselisib + Fulvestrant Versus Placebo + Fulvestrant in Participants With Advanced or Metastatic Breast Cancer Who Have Disease Recurrence or Progression During or After Aromatase Inhibitor Therapy (SANDPIPER)	Terminated	USA \| NLD \| ITA \| FRA \| ESP \| DEU \| CAN \| AUT \| AUS	19
NCT04253561	Phase I	Ipatasertib + Pertuzumab + Trastuzumab	Ipatasertib + Pertuzumab +Trastuzumab in Advanced HER2+ PI3KCA-mutant Breast Cancer Patients (IPATHER)	Recruiting	ESP	0
NCT01776008	Phase II	Goserelin + MK2206	Akt Inhibitor MK-2206 and Anastrozole With or Without Goserelin Acetate in Treating Patients With Stage II-III Breast Cancer	Terminated	USA	0
NCT04958226	Phase I	Capivasertib + Midazolam	A Study to Assess the Effect of Capivasertib on Midazolam in Patients With Advanced Solid Tumours	Completed	USA	0
NCT04589845	Phase II	Alectinib Ado-trastuzumab emtansine Ipatasertib Inavolisib Entrectinib Atezolizumab Idasanutlin	Tumor-Agnostic Precision Immuno-Oncology and Somatic Targeting Rational for You (TAPISTRY) Platform Study	Recruiting	USA \| NZL \| NLD \| ITA \| GBR \| FRA \| ESP \| DEU \| CAN \| BEL \| AUS	14
NCT05810870	Phase II	Eribulin + MEN1611 MEN1611	PIK3CA/PTEN-altered Advanced Breast Cancer Treated With MEN1611 Monotherapy or in Combination With Eribulin (SABINA)	Recruiting	ESP	0
NCT04192981	Phase I	GDC-0084	GDC-0084 With Radiation Therapy for People With PIK3CA-Mutated Solid Tumor Brain Metastases or Leptomeningeal Metastases	Active, not recruiting	USA	0
NCT03155620	Phase II	Tazemetostat Larotrectinib LY3023414 Vemurafenib Palbociclib Olaparib Ulixertinib Erdafitinib Selumetinib Ensartinib	Targeted Therapy Directed by Genetic Testing in Treating Pediatric Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphomas, or Histiocytic Disorders (The Pediatric MATCH Screening Trial)	Recruiting	USA \| CAN \| AUS	1
NCT03032406	Phase II	Everolimus + Hydroxychloroquine Everolimus Hydroxychloroquine	CLEVER Pilot Trial: A Phase II Pilot Trial of HydroxyChLoroquine, EVErolimus or the Combination for Prevention of Recurrent Breast Cancer	Active, not recruiting	USA	0
NCT02961283	Phase I	ASN003	Study of ASN003 in Subjects With Advanced Solid Tumors	Terminated	USA	0
NCT01971515	Phase I	M2698	First-in-Human Dose Escalation Trial in Subjects With Advanced Malignancies	Completed	USA	0
NCT05933395	Phase II	Abemaciclib + Fulvestrant Fulvestrant + Neratinib Alpelisib + Fulvestrant Everolimus + Fulvestrant	Genetically-informed Therapy for ER+ Breast Cancer Post-CDK4/6 Inhibitor (GERTRUDE)	Recruiting	USA	0
NCT01470209	Phase I	Buparlisib + Everolimus	A Phase I Study of BKM120 and Everolimus in Advanced Solid Malignancies	Completed	USA	0
NCT05625087	Phase II	Fulvestrant + Ribociclib Alpelisib + Fulvestrant	Detection of Tumor DNA in the Blood of Patients Receiving Standard Therapy for Hormone Receptor-positive (HR+) Non-HER2 Expressing (HER2-) Metastatic Breast Cancer as a Tool to Select Those Who May Benefit From the Next Course of Fulvestrant in Combination With Alpelisib or Ribociclib (SAFIR 03)	Recruiting	FRA	0
NCT04551521	Phase II	Atezolizumab Atezolizumab + Ipatasertib Atezolizumab + Pertuzumab + Trastuzumab Atezolizumab + Cobimetinib Alectinib Atezolizumab + Cobimetinib + Vemurafenib	CRAFT: The NCT-PMO-1602 Phase II Trial	Recruiting	DEU	0
NCT03673787	Phase Ib/II	Atezolizumab + Ipatasertib	A Trial of Ipatasertib in Combination With Atezolizumab (IceCAP)	Unknown status	GBR	0
NCT04317105	Phase Ib/II	Copanlisib + Ipilimumab + Nivolumab Copanlisib + Nivolumab	Testing the Addition of an Anti-cancer Drug, Copanlisib, to the Usual Immunotherapy (Nivolumab With or Without Ipilimumab) in Patients With Advanced Solid Cancers That Have Changes in the Following Genes: PIK3CA and PTEN	Active, not recruiting	USA \| CAN	0
NCT05082025	Phase II	Copanlisib + Fulvestrant	Phase 2 Study of PI3K Inhibitor Copanlisib in Combination With Fulvestrant in Selected ER+ and/or PR+ Cancers With PI3K (PIK3CA, PIK3R1) and/or PTEN Alterations	Active, not recruiting	USA	0
NCT03941782	Phase 0	Alpelisib	Compassionate Use of BYL 719 Alpelisib	No longer available	USA	0
NCT04108858	Phase Ib/II	Copanlisib + Pertuzumab + Trastuzumab Pertuzumab + Trastuzumab	Testing the Addition of an Anti-cancer Drug, Copanlisib, to the Usual Maintenance Treatment (Trastuzumab and Pertuzumab) After Initial Chemotherapy in a Phase Ib/II Trial for Advanced HER2 Positive Breast Cancer	Terminated	USA	0
NCT05392608	Phase II	Alpelisib + Fulvestrant	SEQUence of Endocrine Therapy in Advanced Luminal Breast Cancer (SEQUEL-Breast) (SEQUEL-Breast)	Recruiting	NLD	0
NCT05230810	Phase Ib/II	Alpelisib + Fulvestrant + Tucatinib	Clinical Trial of Alpelisb and Tucatinib in Patients With PIK3CA-Mutant HER2+ Metastatic Breast Cancer.	Recruiting	USA	0
NCT01833169	Phase II	Buparlisib	BKM120 for Patients With PI3K-activated Tumors	Completed	USA	0
NCT02920450	Phase Ib/II	Carboplatin + Gedatolisib + Paclitaxel	Study of Paclitaxel, Carboplatin, and PF-05212384 in Advanced or Metastatic NSCLC (UF-STO-LUNG-002)	Terminated	USA	0
NCT05759949	Phase I	Fulvestrant + RLY-5836 RLY-5836 Fulvestrant + Palbociclib + RLY-5836 Abemaciclib + Fulvestrant + RLY-5836 Fulvestrant + Ribociclib + RLY-5836	First-in-Human Study of RLY-5836 in Advanced Breast Cancer and Other Solid Tumors	Active, not recruiting	USA	0
NCT03317119	Phase I	Trametinib + Trifluridine-tipiracil hydrochloride	Trametinib and Trifluridine and Tipiracil Hydrochloride in Treating Patients With Colon or Rectal Cancer That is Advanced, Metastatic, or Cannot Be Removed by Surgery	Completed	USA	0
NCT05300048	Phase I	Serabelisib Nab-paclitaxel + Serabelisib	Combination of Serabelisib and Insulin Suppressing Diet With or Without Nab-paclitaxel in Subjects With Advanced Solid Tumors With PIK3CA Mutations	Active, not recruiting	USA	0
NCT04632992	Phase II	Ipatasertib Atezolizumab + Capecitabine Entrectinib Atezolizumab + Docetaxel Ado-trastuzumab emtansine + Atezolizumab Capecitabine + Pertuzumab/trastuzumab/hyaluronidase-zzxf Paclitaxel + Pertuzumab/trastuzumab/hyaluronidase-zzxf Alectinib Inavolisib Pertuzumab/trastuzumab/hyaluronidase-zzxf Docetaxel + Pertuzumab/trastuzumab/hyaluronidase-zzxf Atezolizumab + Paclitaxel Ado-trastuzumab emtansine + Tucatinib	A Study Evaluating Targeted Therapies in Participants Who Have Advanced Solid Tumors With Genomic Alterations or Protein Expression Patterns Predictive of Response (MyTACTIC)	Completed	USA	0
NCT05090358	Phase II	Alpelisib + Fulvestrant Alpelisib + Canagliflozin + Fulvestrant	Preventing High Blood Sugar in People Being Treated for Metastatic Breast Cancer	Active, not recruiting	USA	0
NCT04216472	Phase II	Alpelisib + Nab-paclitaxel	Nab-paclitaxel and Alpelisib for the Treatment of Anthracycline Refractory Triple Negative Breast Cancer With PIK3CA or PTEN Alterations	Active, not recruiting	USA	0
NCT02549989	Phase II	LY3023414	Study of LY3023414 for the Treatment of Recurrent or Persistent Endometrial Cancer	Completed	USA	0
NCT05332561	Phase II	Olaparib Ipatasertib Sacituzumab govitecan-hziy Inavolisib Pertuzumab/trastuzumab/hyaluronidase-zzxf Atezolizumab	Genomics Guided Targeted Post-neoadjuvant Therapy in Patients With Early Breast Cancer (COGNITION-GUIDE)	Recruiting	DEU	0
NCT05010096	Phase I	Copanlisib + Elimusertib	BAY1895344 and Copanlisib for the Treatment of Molecularly Selected Patients With Advanced Solid Tumors	Withdrawn		0
NCT05307705	Phase I	Abemaciclib + Anastrozole + LOXO-783 Abemaciclib + Exemestane + LOXO-783 Abemaciclib + Letrozole + LOXO-783 LOXO-783 + Paclitaxel Fulvestrant + LOXO-783 LOXO-783 + LY3484356 Abemaciclib + Fulvestrant + LOXO-783 Abemaciclib + LOXO-783 + LY3484356 Letrozole + LOXO-783 LOXO-783 Anastrozole + LOXO-783 Exemestane + LOXO-783	A Study of LOXO-783 in Patients With Breast Cancer/Other Solid Tumors (PIKASSO-01)	Recruiting	USA \| ITA \| GBR \| FRA \| ESP \| DEU \| CAN \| BEL \| AUS	4
NCT03213678	Phase II	LY3023414	Samotolisib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With TSC or PI3K/MTOR Mutations (A Pediatric MATCH Treatment Trial)	Active, not recruiting	USA	1
NCT02761694	Phase I	ARQ 751 + Paclitaxel ARQ 751 ARQ 751 + Fulvestrant	ARQ 751 as a Single Agent or in Combination With Other Anti-Cancer Agents, in Solid Tumors With PIK3CA / AKT / PTEN Mutations	Terminated	USA	0
NCT04586335	Phase I	CYH33 + Olaparib	Study of CYH33 in Combination With Olaparib an Oral PARP Inhibitor in Patients With Advanced Solid Tumors.	Terminated	USA \| AUS	1
NCT03842228	Phase I	Copanlisib + Durvalumab + Olaparib	Testing the Combination of the Anti-cancer Drugs Copanlisib, Olaparib, and MEDI4736 (Durvalumab) in Patients With Advanced Solid Tumors With Selected Mutations	Active, not recruiting	USA	0
NCT03457896	Phase II	Cetuximab + Neratinib Neratinib + Trastuzumab	Study of Neratinib +Trastuzumab or Neratinib + Cetuximab in Patients With KRAS/NRAS/BRAF/PIK3CA Wild-Type Metastatic Colorectal Cancer by HER2 Status	Unknown status	USA	0
NCT01960023	Phase Ib/II	Cetuximab + Neratinib	Safety and Efficacy Study of Neratinib and Cetuximab to Treat Patients With Quadruple Wild-Type Metastatic Colorectal Cancer	Withdrawn	USA	0
NCT06239467	Phase I	OKI-219 + Trastuzumab OKI-219 Fulvestrant + OKI-219	First-in-Human Study of OKI-219 in Advanced Solid Tumors and Advanced Breast Cancer (PIKture-01)	Recruiting	USA	0

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