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Gene Symbol PIK3R2
Synonyms MPPH | MPPH1 | p85 | p85-BETA | P85B
Gene Description PIK3R2, phosphoinositide-3-kinase regulatory subunit 2, encodes a PI3K regulatory subunit that recruits active PI3K/AKT signaling pathway kinases via its SH2 domain (PMID: 22733740). PIK3R2 expression is correlated with tumor progression (PMID: 22733740) and is regulated by miR-126 microRNA in several cancer types (PMID: 21249429, PMID: 27698796, PMID: 27578985), and likely plays an oncogenic role in cancer (PMID: 30961830).


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