Gene Detail

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Gene Symbol

LRP1B

Synonyms

LRP-1B | LRP-DIT | LRPDIT

Gene Description

LRP1B, LDL receptor related protein 1B, is a tumor repressor (PMID: 20095042) and a cell surface receptor (PMID: 11384978) that may negatively regulate urokinase plasminogen activator receptor regeneration and cell migration (PMID: 12194987). Mutations in LRP1B are frequently observed in melanoma, lung cancer, esophageal squamous-cell carcinoma, head and neck squamous cancer, and gastric cancer (PMID: 31164891) and may be associated with high tumor mutational burden (PMID: 31164891, PMID: 31493933).

NCBI Gene ID	Chromosome	Map Location	Canonical Transcript	Gene Role
53353	2	2q22.1-q22.2	NM_018557	Tumor suppressor (PMID: 30606230)