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Gene Symbol PMS1
Synonyms HNPCC3 | hPMS1 | MLH2 | PMSL1
Gene Description PMS1, PMS1 homolog 1, mismatch repair system component, is a MutL homolog that interacts with MLH1 and has a putative role in DNA mismatch repair (PMID: 11920679). Germline PMS1 mutations are associated with Lynch syndrome (PMID: 19466295) and somatic mutations have been identified in multiple myeloma, colorectal cancer, and ovarian cancer (PMID: 30809292, PMID: 24614649, PMID: 24333356).
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