Missing content? – Request curation!
Request curation for specific Genes, Variants, or PubMed publications.
Have questions, comments, or suggestions? - Let us know!
Email us at : firstname.lastname@example.org
|Synonyms||PLOSL2 | TREM-2 | Trem2a | Trem2b | Trem2c|
|Gene Description||TREM2, triggering receptor expressed on myeloid cells 2, encodes a transmembrane receptor protein that associates with DAP12 and plays a role in regulating inflammatory signaling as well as phagocytosis (PMID: 31649511, PMID: 24990881), chemotaxis (PMID: 28483841), and lipid metabolism in microglia (PMID: 31902528). Decreased TREM2 expression has been demonstrated in hepatocellular carcinoma (PMID: 30683932), whereas elevated levels of TREM2 have been observed in glioma (PMID: 26506595).|