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Gene Symbol TREM2
Synonyms PLOSL2 | TREM-2 | Trem2a | Trem2b | Trem2c
Gene Description TREM2, triggering receptor expressed on myeloid cells 2, encodes a transmembrane receptor protein that associates with DAP12 and plays a role in regulating inflammatory signaling as well as phagocytosis (PMID: 31649511, PMID: 24990881), chemotaxis (PMID: 28483841), and lipid metabolism in microglia (PMID: 31902528). Decreased TREM2 expression has been demonstrated in hepatocellular carcinoma (PMID: 30683932), whereas elevated levels of TREM2 have been observed in glioma (PMID: 26506595).
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