Gene Detail

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Gene Symbol ATR
Synonyms FCTCS | FRP1 | MEC1 | SCKL | SCKL1
Gene Description ATR, ATR serine/threonine kinase, is involved in regulation of the DNA damage response and mediation of cell-cycle checkpoints (PMID: 25512053). Loss of function ATR mutations have been identified in melanoma (PMID: 28273450), and inhibition of Atr selectively sensitizes cancerous cells to radiation and chemotherapy (PMID: 23583268, PMID: 31836456, PMID: 29054375).

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Molecular Profile Protein Effect Treatment Approaches
ATR A1896D unknown
ATR A1896T unknown
ATR A1934D unknown
ATR A2002G unknown
ATR A2165V unknown
ATR A615S unknown
ATR amp no effect
ATR C347* loss of function - predicted
ATR D1380Y unknown
ATR D1470N unknown
ATR D155E unknown
ATR D1560N unknown
ATR D2118N unknown
ATR D2331Y unknown
ATR D2494E loss of function
ATR D983N unknown
ATM del ATR dec exp
ATR dec exp no effect
ATR del loss of function
ATR E1059* loss of function - predicted
ATR E1229* loss of function - predicted
ATR E1375G unknown
ATR E1602D unknown
ATR E2011K unknown
ATR E2103A unknown
ATR E2378V unknown
ATR E254G unknown
ATR E2626* unknown
ATR E91* loss of function - predicted
ATR F676fs loss of function - predicted
ATR F732L unknown
ATR G1181C unknown
ATR G1181F unknown
ATR G1181S unknown
ATR G1181V unknown
ATR G2530C unknown
ATR H2153R unknown
ATR H2203N unknown
ATR H4R unknown
ATR H90Y unknown
ATR I1526V unknown
ATR I1831S unknown
ATR I1851V unknown
ATR I219V unknown
ATR I493M unknown
ATR I774fs loss of function - predicted
ATR I774Nfs*3 loss of function - predicted
ATR I774Nfs*5 loss of function - predicted
ATR I774Yfs*5 loss of function - predicted
ATR inact mut loss of function
ATR K2221E unknown
ATR K2310N unknown
ATR K297N unknown
ATR K764E unknown
ATR K771fs loss of function - predicted
ATR L1361* loss of function - predicted
ATR L1361V unknown
ATR L1397M unknown
ATR L1707I unknown
ATR L1746I unknown
ATR L1834F unknown
ATR L2076V unknown
ATR L2306F unknown
ATR L2593I unknown
ATR L298R unknown
ATR M1162I no effect
ATR M211I unknown
ATR M211T unknown
ATR M328V unknown
ATR M335I unknown
ATR mutant unknown
ATR over exp no effect ATR Inhibitor
ATR P1530Q unknown
ATR positive unknown
ATR Q1732L unknown
ATR Q1845* loss of function - predicted
ATR Q2635H unknown
ATR Q412* loss of function - predicted
ATR R1015Q unknown
ATR R1025C unknown
ATR R109L unknown
ATR R109W unknown
ATR R1183Q unknown
ATR R1201C unknown
ATR R1368* loss of function - predicted
ATR R1412Q unknown
ATR R1503* loss of function - predicted
ATR R1647C unknown
ATR R1724M unknown
ATR R177Q unknown
ATR R1814Efs*10 loss of function - predicted
ATR R1814Kfs*8 loss of function - predicted
ATR R1886* loss of function - predicted
ATR R1886Q unknown
ATR R2356C unknown
ATR R2407C unknown
ATR R2407H unknown
ATR R2425Q unknown
ATR R2514C unknown
ATR R515H unknown
ATR R968I unknown
ATR R989C unknown
ATR S1142G unknown
ATR S1325C unknown
ATR S1325N unknown
ATR S1645F unknown
ATR S601F loss of function
ATR S684Y unknown
ATR S902Y unknown
ATR T1401A unknown
ATR T2516I unknown
ATR T2580N unknown
ATR T541I unknown
ATR V316I unknown
ATR V915A unknown
ATR V959M unknown
ATR W1591L unknown
ATR W2035C unknown
ATR wild-type no effect
ATR Y1404* loss of function - predicted
ATR Y2132* loss of function - predicted
ATR Y2132D unknown
ATR Y2637C unknown