Gene Detail

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Gene Symbol TET2
Synonyms KIAA1546 | MDS
Gene Description TET2, methylcytosine dioxygenase TET2, is a member of the ten-eleven-translocation family of genes that plays a role in DNA methylation and is involved in hematopoesis (PMID: 26099018, PMID: 25510268, PMID: 27848178). TET2 has been identified as a tumor suppressor in hematological malignancies, and mutations in TET2 are common in hematological cancers including myelodysplastic syndrome, chronic myelomoncytic leukemia, and atypical CML (PMID: 26099018, PMID: 22240200, PMID: 30138727) and epigenetic dysregulation has been observed in glioblastoma (PMID: 29899831).

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Molecular Profile Protein Effect Treatment Approaches
TET2 A1505T loss of function
TET2 A855S unknown
TET2 C1193W loss of function - predicted
TET2 C1221Y unknown
TET2 C1273F unknown
TET2 C1374Y unknown
TET2 C1378F unknown
TET2 C1396R unknown
TET2 C784S unknown
TET2 D1143fs loss of function - predicted
TET2 D1242V loss of function - predicted
TET2 D1384A loss of function - predicted
TET2 D1384V unknown
TET2 D1427Y unknown
TET2 F1377A loss of function - predicted
TET2 G1256D loss of function - predicted
TET2 G1275E unknown
TET2 G1288S unknown
TET2 G1861R loss of function
TET2 G355D unknown
TET2 H1219N unknown
TET2 H1380L unknown
TET2 H1380Y unknown
TET2 H1382Y loss of function - predicted
TET2 H1778R no effect - predicted
TET2 H1868D unknown
TET2 H1881Q loss of function - predicted
TET2 H1881R loss of function - predicted
TET2 H1904R loss of function - predicted
TET2 H924R unknown
TET2 I1762V no effect
TET2 I1873T loss of function - predicted
TET2 I812fs loss of function - predicted
TET2 inact mut loss of function
TET2 K1171fs loss of function - predicted
TET2 K67fs loss of function - predicted
TET2 L1322P unknown
TET2 L1326S unknown
TET2 L1514H unknown
TET2 L1721W no effect - predicted
TET2 L1801F unknown
TET2 L34F unknown
TET2 L360W unknown
TET2 loss loss of function
TET2 M1293A unknown
TET2 M1701I unknown
TET2 mutant unknown
ASXL1 mut TET2 mut
ASXL1 wild-type TET2 mut
TET2 N1387A loss of function - predicted
TET2 P1617H loss of function
TET2 P1723S no effect - predicted
TET2 P174H unknown
TET2 P1889H unknown
TET2 P29R unknown
TET2 P363L no effect - predicted
TET2 Q1084P unknown
TET2 Q1389* loss of function - predicted
TET2 Q1524H unknown
TET2 Q1540K unknown
TET2 Q1624H unknown
TET2 Q742* loss of function - predicted
TET2 Q876* loss of function - predicted
TET2 R1261G loss of function - predicted
TET2 R1262A loss of function - predicted
TET2 R1302G loss of function - predicted
TET2 R1359C unknown
TET2 R1359H unknown
TET2 R1452* loss of function - predicted
TET2 R1572Q unknown
TET2 R1896M loss of function - predicted
TET2 R1896S loss of function - predicted
TET2 R2000I unknown
TET2 R506* loss of function - predicted
TET2 S1039L unknown
TET2 S1290A unknown
TET2 S1303N unknown
TET2 S1369* loss of function - predicted
TET2 S1607L unknown
TET2 S1758* loss of function - predicted
TET2 S1870L unknown
TET2 S358G unknown
TET2 S393Lfs*34 loss of function - predicted
TET2 T1884A loss of function - predicted
TET2 V1718L unknown
TET2 W1291R loss of function
TET2 W1291_N1296delinsGGSGGS loss of function - predicted
TET2 wild-type no effect
TET2 Y1294A unknown
TET2 Y1295A unknown
TET2 Y1902A loss of function - predicted
TET2 Y867H unknown