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|Gene Description||PPL, periplakin, is a membrane-associated protein that functions in the formation of the cornified cell envelope in keratinocytes (PMID: 24942859). A PPL-NTRK1 fusion has been observed in thyroid carcinoma (PMID: 25384085) and loss of Ppl expression has been observed in colorectal carcinoma (PMID: 28068625) and urothelial carcinoma (PMID: 24942859).|