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Gene Symbol SLFN12
Synonyms SLFN3
Gene Description SLFN12, schlafen family member 12, encodes a member of the SLFN family that plays a role in cell differentiation (PMID: 24768141, PMID: 31260507), apoptosis (PMID: 31420216), and T cell activation (PMID: 27718235, PMID: 30379917). SLFN12 mutations have been identified in Sezary syndrome (PMID: 24689486), and decreased Slfn12 expression has been identified in triple-negative breast cancer (PMID: 31838790).
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