Gene Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, variants, or PubMed publications.

Have questions, comments or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Gene Symbol MCM10
Synonyms CNA43 | DNA43 | PRO2249
Gene Description MCM10, minichromosome maintenance 10 replication initiation factor, encodes a protein that binds to single-stranded and double-stranded DNA, playing multiple roles in DNA replication (PMID: 23332289, PMID: 24662891), including the assembly of the replisome during initiation (PMID: 17761813, PMID: 10783164), replication elongation (PMID: 28270517), and DNA damage prevention (PMID: 17699597, PMID: 24726359). Increased expression of MCM10 has been identified in urothelial carcinoma (PMID: 27780919), lung cancer (PMID: 31638210), and breast cancer (PMID: 30135378).


Additional content available in CKB BOOST