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Gene Symbol TMEM127
Gene Description TMEM127, transmembrane protein 127, acts as part of a lysosomal complex that plays a role in regulation of mTORC1 signaling (PMID: 21447639, PMID: 29547888). TMEM127 germline mutations are associated with pheochromocytoma and paraganglioma (PMID: 20154675, PMID: 20923864, PMID: 22419703), and have also been identified in renal cell carcinoma (PMID: 24334765).
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