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Gene Symbol PRKACA
Synonyms CAFD1 | PKACA | PPNAD4
Gene Description PRKACA, protein kinase cAMP-activated catalytic subunit alpha, encodes the catalytic subunit of protein kinase A, which activates cAMP-dependent signaling pathways and is involved in diverse biological processes including cardiovascular and adrenal cortex functions (PMID: 26042218, PMID: 26687711, PMID: 29205368). PRKACA mutations have been identified in cardiac (PMID: 28369983) and adrenal (PMID: 26042218) tumors, and a DNAJB1-PRKACA fusion has been identified in fibrolamellar hepatocellular carcinoma (PMID: 24578576), and in pancreatic and bile duct cancer (PMID: 31676785).
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