Gene Detail

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Gene Symbol AXL
Synonyms ARK | JTK11 | Tyro7 | UFO
Gene Description AXL, AXL receptor tyrosine kinase, is a receptor tyrosine kinase, which promotes growth, migration, and survival of tumor cells through activation of Mapk signaling (PMID: 28072762). Activation and overexpression of AXL has been associated with resistance to chemotherapeutic agents and targeted therapies (PMID: 28251492), in both solid and hematological tumors (PMID: 32148495).

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Molecular Profile Protein Effect Treatment Approaches
AXL A273V unknown
AXL A674V unknown
AXL A857V no effect - predicted
AXL act mut gain of function
AXL amp no effect
AXL - MBIP gain of function - predicted
AXL C117R unknown
AXL C311F unknown
AXL D382G unknown
AXL E388D unknown
AXL E524K unknown
AXL E818K unknown
AXL F631S unknown
AXL F652L unknown
AXL G331A unknown
AXL G335fs loss of function - predicted
AXL G413V loss of function - predicted
AXL G413W unknown
AXL G415A unknown
AXL G46V unknown
AXL G517S unknown
AXL G692R unknown
AXL G736R unknown
AXL G736W loss of function - predicted
AXL G73V unknown
AXL G89D unknown
AXL H670Q unknown
AXL I466L unknown
AXL I619V unknown
AXL I656N unknown
AXL I758M unknown
AXL inact mut loss of function
AXL K476T unknown
AXL K567M loss of function - predicted
AXL K567R loss of function - predicted
AXL L423Q loss of function - predicted
AXL L455I unknown
AXL L54F unknown
AXL L54I unknown
AXL L693P unknown
AXL L721P unknown
AXL M569I unknown
AXL M589K unknown
AXL mutant unknown
AXL N266D unknown
AXL N43T unknown
AXL N677I unknown
AXL negative loss of function
AXL over exp no effect
EML4 - ALK AXL over exp
AXL Y779F AXL over exp
AXL Y866F AXL over exp
AXL Y821F AXL over exp
AXL over exp BRAF V600E
AXL P168S unknown
AXL P337Lfs*29 loss of function - predicted
AXL P444S no effect - predicted
AXL P595S unknown
AXL P645H unknown
AXL P64S unknown
AXL P811S unknown
AXL positive unknown
AXL pos TYRO3 over exp
ALK R1275Q AXL pos
ALK F1174L AXL pos
AXL pos FLT3 exon 14 ins
AXL Q59H unknown
AXL Q764R unknown
AXL Q83R unknown
AXL R217H unknown
AXL R229C unknown
AXL R295W unknown
AXL R308C unknown
AXL R357W unknown
AXL R368Q unknown
AXL R368W unknown
AXL R427C unknown
AXL R475Q unknown
AXL R48W unknown
AXL R506C no effect - predicted
AXL R506H no effect - predicted
AXL R507W unknown
AXL R527L no effect - predicted
AXL R527W unknown
AXL R55Q unknown
AXL R610Q unknown
AXL R671Q unknown
AXL R71W unknown
AXL R800L no effect - predicted
AXL rearrange unknown
AXL S128F unknown
AXL S265A unknown
AXL S285L unknown
AXL S341G unknown
AXL S685F unknown
AXL S694F unknown
AXL T343M unknown
AXL T568M no effect - predicted
AXL V289M unknown
AXL V421L unknown
AXL V459M unknown
AXL V60F unknown
AXL V618I unknown
AXL W426R no effect - predicted
AXL W69* loss of function - predicted
AXL wild-type no effect
AXL Y367C unknown
AXL Y371C unknown
AXL Y779F unknown
AXL Y821F loss of function - predicted
AXL Y866F no effect - predicted