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Gene Symbol MAPK7
Synonyms BMK1 | ERK4 | ERK5 | PRKM7
Gene Description MAPK7, mitogen-activated protein kinase 7, is a member of the Map kinase family that plays a role in diverse biological processes including cell proliferation and regulation of the cell cycle during the G1/S and G2/M transitions (PMID: 27713878) and demonstrates involvement in muscle cell differentiation (PMID: 11520859) and cardiovascular development (PMID: 17875982). MAPK7 amplification has been observed in hepatocellular carcinoma (PMID: 18973138) and lung cancer (PMID: 26040563), and overexpression has been identified in several tumor types including breast cancer (PMID: 15378007), prostate cancer (PMID: 12618764), squamous cell carcinoma, clear cell renal carcinoma, and osteosarcoma (PMID: 34299213).
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