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Gene Symbol PTGS2
Synonyms COX-2 | COX2 | GRIPGHS | hCox-2 | PGG/HS | PGHS-2 | PHS-2
Gene Description PTGS2, prostaglandin-endoperoxide synthase 2, encodes an cyclooxygenase that is responsible for catalyzing the first step in the synthesis of prostaglandins upon induction via inflammatory stimuli within macrophages, thereby playing a key role in the immune response (PMID: 15173859, PMID: 25619459). PTGS2 overexpression has been observed in several tumor types including colorectal cancer, liver cancer, pancreatic cancer, breast cancer, and lung cancer (PMID: 26549987).
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