Gene Detail

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Gene Symbol PTK7
Synonyms CCK-4 | CCK4
Gene Description PTK7, protein tyrosine kinase 7 (inactive), is a catalytically-inactive receptor protein tyrosine kinase that is involved in non-canonical Wnt signaling and plays a role in cell migration (PMID: 27438854, PMID: 27499181). Dysregulation of Ptk7 expression has been demonstrated in various tumor types, including colorectal cancer and ovarian cancer (PMID: 27499181, PMID: 25550828) and decreased expression has been reported in invasive ductal breast cancer (PMID: 31933919), while overexpression has been observed in hepatocellular carcinoma (PMID: 31730575) and cervical cancer (PMID: 30944666).


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