Gene Detail


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Gene Symbol RAD21
Synonyms CDLS4 | hHR21 | HR21 | HRAD21 | MCD1 | MGS | NXP1 | SCC1
Gene Description RAD21, RAD21 cohesin complex component, is a double-strand-break repair protein and member of the cohesion complex, which is responsible for maintaining sister chromatid segregation during the S-phase of the mitotic cycle (PMID: 22145905). Amplification and overexpression of Rad21 has been observed in several cancer types including breast, prostate, colorectal (PMID: 21255398, PMID: 24548858), and mutations have been identified in acute myeloid leukemia (PMID: 29288251).


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Variant Impact Protein Effect Variant Description Associated with drug Resistance
inact mut unknown loss of function RAD21 inact mut indicates that this variant results in a loss of function of the Rad21 protein. However, the specific amino acid change has not been identified.
mutant unknown unknown RAD21 mutant indicates an unspecified mutation in the RAD21 gene.