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|Synonyms||CDLS4 | hHR21 | HR21 | HRAD21 | MCD1 | MGS | NXP1 | SCC1|
|Gene Description||RAD21, RAD21 cohesin complex component, is a double-strand-break repair protein and member of the cohesion complex, which is responsible for maintaining sister chromatid segregation during the S-phase of the mitotic cycle (PMID: 22145905). Amplification and overexpression of Rad21 has been observed in several cancer types including breast, prostate, colorectal (PMID: 21255398, PMID: 24548858), and mutations have been identified in acute myeloid leukemia (PMID: 29288251).|
|Variant||Impact||Protein Effect||Variant Description||Associated with drug Resistance|
|inact mut||unknown||loss of function||RAD21 inact mut indicates that this variant results in a loss of function of the Rad21 protein. However, the specific amino acid change has not been identified.|
|mutant||unknown||unknown||RAD21 mutant indicates an unspecified mutation in the RAD21 gene.|