Gene Detail

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Gene Symbol RAD21
Synonyms CDLS4 | hHR21 | HR21 | HRAD21 | MCD1 | MGS | NXP1 | SCC1
Gene Description RAD21, RAD21 cohesin complex component, is a double-strand-break repair protein and member of the cohesion complex, which is responsible for maintaining sister chromatid segregation during the S-phase of the mitotic cycle (PMID: 22145905). Amplification and overexpression of Rad21 has been observed in several cancer types including breast, prostate, colorectal (PMID: 21255398, PMID: 24548858), and mutations have been identified in acute myeloid leukemia (PMID: 29288251).

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Molecular Profile Protein Effect Treatment Approaches
RAD21 A377G unknown
RAD21 A595T unknown
RAD21 amp no effect
RAD21 D116E unknown
RAD21 D118V unknown
RAD21 D123Y unknown
RAD21 D125H unknown
RAD21 D166N unknown
RAD21 D213E unknown
RAD21 D292H unknown
RAD21 D333H unknown
RAD21 D333N unknown
RAD21 D414E unknown
RAD21 D484G unknown
RAD21 D484H unknown
RAD21 D550Y unknown
RAD21 D95H unknown
RAD21 E419K unknown
RAD21 E453Dfs*3 unknown
RAD21 E495D unknown
RAD21 E508Q unknown
RAD21 E98Q unknown
RAD21 F114C unknown
RAD21 F373L unknown
RAD21 F82I unknown
RAD21 G150V unknown
RAD21 G223* loss of function - predicted
RAD21 G240S unknown
RAD21 G62E unknown
RAD21 H629Y unknown
RAD21 I154T unknown
RAD21 I44V unknown
RAD21 inact mut loss of function
RAD21 K29T unknown
RAD21 K335N unknown
RAD21 K596E unknown
RAD21 L341R unknown
RAD21 L564F unknown
RAD21 L567V unknown
RAD21 L582P unknown
RAD21 M362L unknown
RAD21 mutant unknown
RAD21 over exp no effect
RAD21 P283L unknown
RAD21 P426S unknown
RAD21 P443L unknown
RAD21 P506L unknown
RAD21 P509H unknown
RAD21 P509L unknown
RAD21 Q214* unknown
RAD21 Q214K unknown
RAD21 Q293E unknown
RAD21 Q474* unknown
RAD21 Q551* unknown
RAD21 R168C unknown
RAD21 R391H unknown
RAD21 R437H unknown
RAD21 R54Q unknown
RAD21 R54W unknown
RAD21 R586* unknown
RAD21 R65Q unknown
RAD21 R90W unknown
RAD21 S200C unknown
RAD21 S374F unknown
RAD21 T390A unknown
RAD21 V129L unknown
RAD21 V284I unknown
RAD21 V32M unknown
RAD21 V41M unknown
RAD21 W18C unknown
RAD21 wild-type no effect
RAD21 Y617C unknown