Missing content? – Request curation!
Request curation for specific Genes, variants, or PubMed publications.
Have questions, comments or suggestions? - Let us know!
Email us at : email@example.com
|Synonyms||Bcl-2 | PPP1R50|
|Gene Description||BCL2, BCL2 apoptosis regulator, belongs to the BCL-2 family of proteins and plays a role in the regulation of cell death, specifically preventing apoptosis and some processes related to necrosis (PMID: 9990505). Overexpression of BCL2 has been observed in a variety of solid tumors, including lung, ovary, and breast, and amplification has been identified in DLBCL (PMID: 26556430, PMID: 9242549), a fusion with IGH has been observed in high-grade B-cell lymphoma (PMID: 32183313, PMID: 31695002), and BCL2 mutations may confer resistance to BH3-mimetics (PMID: 31951646).|