Gene Detail

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Gene Symbol RET
Synonyms CDHF12 | CDHR16 | HSCR1 | MEN2A | MEN2B | MTC1 | PTC | RET-ELE1
Gene Description RET, ret proto-oncogene, is a receptor tyrosine kinase that activates MAPK and PI3K/AKT pathways and regulates cell growth and differentiation (PMID: 24561444, PMID: 29134959, PMID: 32094155). RET germline mutations result in MEN2 syndromes and familial medullary thyroid carcinoma (PMID: 20930041, PMID: 24561444) and somatic RET activating mutations, fusions, and Ret amplification and/or overexpression has been associated with a variety of cancers including lung (PMID: 30257958) and colorectal (PMID: 30210625, PMID: 30038711).
ACMG Incidental List v2.0:
Yes, Multiple endocrine neoplasia, type 2a (PMID: 27854360)
Yes, Multiple endocrine neoplasia, type 2b (PMID: 27854360)
Yes, Familial medullary thyroid carcinoma (PMID: 27854360)

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Molecular Profile Protein Effect Treatment Approaches
RET A1105V no effect - predicted
RET A274G unknown
RET A756D unknown
RET A756V unknown
RET A807V unknown
RET A883F gain of function RET Inhibitor
RET A883T gain of function - predicted RET Inhibitor
RET A883X unknown
RET A919V unknown
RET act mut gain of function RET Inhibitor
RET amp no effect RET Inhibitor
ROS1 fusion ERBB2 amp FGFR3 amp RET amp
RET C515S gain of function RET Inhibitor
RET C515W gain of function RET Inhibitor
RET C609F unknown
RET C609G unknown
RET C609R gain of function - predicted
RET C609S gain of function - predicted RET Inhibitor
RET C609W unknown
RET C609X unknown
RET C609Y gain of function RET Inhibitor
RET C611F unknown
RET C611G unknown
RET C611R unknown
RET C611S unknown
RET C611W gain of function - predicted
RET C611X unknown
RET C611Y gain of function RET Inhibitor
RET C618F gain of function - predicted RET Inhibitor
RET C618G gain of function - predicted
RET C618R gain of function RET Inhibitor
RET C618S gain of function - predicted
RET C618W unknown
RET C618X unknown
RET C618Y gain of function RET Inhibitor
RET C620F unknown
RET C620G unknown
RET C620R gain of function
RET C620S gain of function - predicted
RET C620W unknown
RET C620X unknown
RET C620Y gain of function RET Inhibitor
RET C630F gain of function RET Inhibitor
RET C630G unknown RET Inhibitor
RET C630R gain of function RET Inhibitor
RET C630S unknown RET Inhibitor
RET C630X unknown
RET C630Y gain of function - predicted RET Inhibitor
RET C634F gain of function - predicted RET Inhibitor
RET C634G gain of function - predicted RET Inhibitor
RET C634L gain of function RET Inhibitor
RET C634R gain of function RET Inhibitor
RET C634R RET V804G
RET C634R RET V804M
RET C634R RET Y806C
RET C634R RET Y806E
RET C634R RET Y806F
RET C634S gain of function RET Inhibitor
RET C634W gain of function RET Inhibitor
KDR pos RET C634W
RET C634X unknown
RET C634Y gain of function RET Inhibitor
RET C634_R635insHELC gain of function RET Inhibitor
RET D631A unknown
RET D631G unknown
RET D631N unknown
RET D631Y gain of function RET Inhibitor
RET D631_L633delinsE unknown
RET D631_R635delinsG unknown
RET L629P RET D631_R635delinsG RET V637R
RET D707N loss of function
RET D771N loss of function
RET D898V unknown
RET E1006D unknown
RET E136K unknown
RET E505_G506del gain of function RET Inhibitor
RET E616Q gain of function
RET E623K unknown
RET E623_L633del unknown
RET E632K unknown
RET E632_L633del gain of function - predicted RET Inhibitor
RET E632_T636delinsSS unknown
RET E732K unknown
RET E734K loss of function
RET E762Q loss of function
RET E768D gain of function RET Inhibitor
RET E768N unknown
RET E768X unknown
RET E805K gain of function - predicted RET Inhibitor
RET V804M RET E805K
RET E884K unknown
RET E921K loss of function
RET F185L unknown
RET F329L unknown
RET F612_C620del unknown
RET F893L loss of function
RET F998V unknown
RET fusion unknown
RET G10C unknown
RET G10R unknown
RET G10S unknown
RET G446R unknown
RET G533C gain of function RET Inhibitor
RET G601W unknown
RET G691S gain of function
RET G736R unknown
RET G810A unknown
RET G810C unknown
RET G810R unknown
RET G810S unknown
RET I788N unknown
RET I852M gain of function RET Inhibitor
RET inact mut loss of function
RET K666E gain of function RET Inhibitor
RET K758M loss of function
RET K907E loss of function - predicted
RET L517V unknown
RET L56M no effect
RET L629P unknown
RET L633_C634dup gain of function RET Inhibitor
RET L730I unknown
RET L730V unknown
RET L790F unknown
RET L790X unknown
RET L881V unknown
RET L923H unknown
RET L923I unknown
RET M1009T unknown
RET M1064T unknown
RET M848T gain of function - predicted RET Inhibitor
RET M918T gain of function RET Inhibitor
ATM L804fs ATM S978fs RET M918T
RET V804M RET M918T
RET M918V no effect - predicted RET Inhibitor
RET M918X unknown
RET M980T loss of function
RET mutant unknown
RET over exp no effect
RET P1039L loss of function - predicted
RET P1070S unknown
RET P273L unknown
RET P973L loss of function - predicted
RET positive unknown
RET Q781R unknown
RET R1013del unknown
RET R231H loss of function - predicted
RET R418* loss of function - predicted
RET R57W unknown
RET R600Q unknown
RET R67H unknown
RET R721W unknown
RET R770Q unknown
RET R77H unknown
RET R77L unknown
RET R813Q loss of function
RET R833C gain of function RET Inhibitor
RET R873Q loss of function
RET R873W unknown
RET R886W gain of function
RET R897Q loss of function
RET R912L unknown
RET R912P gain of function - predicted
RET R912Q loss of function
RET R959W unknown
RET R972G loss of function
RET R982C no effect - predicted
RET rearrange unknown
RET S409Y gain of function RET Inhibitor
RET S649L gain of function RET Inhibitor
RET S765P loss of function
RET S767R loss of function
RET S891A gain of function RET Inhibitor
RET S891L unknown
RET S891X unknown
RET S904C unknown
RET V804M RET S904C
RET S904F unknown RET Inhibitor
RET S936F unknown
RET S977R unknown
RET T1038A unknown
RET T278N unknown
RET T278S unknown
RET T338I unknown
RET T742M unknown
RET V125F unknown
RET V253E unknown
RET V292M gain of function RET Inhibitor
RET V637M unknown
RET V637R unknown
RET V648I unknown
RET V738A unknown
RET V778I unknown
RET V804E unknown
RET V804G unknown
RET V804L gain of function RET Inhibitor
RET V804M gain of function RET Inhibitor
RET V804M RET Y806C
RET V804X unknown
RET V871I unknown
RET V915_K916insVHR unknown
RET W85* loss of function - predicted
RET wild-type no effect
RET Y606C gain of function RET Inhibitor
RET Y791F gain of function RET Inhibitor
RET Y791X unknown
RET Y806C gain of function - predicted
RET Y806E unknown
RET Y806F unknown
RET Y806N unknown