Gene Detail


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Gene Symbol APOBEC3G
Synonyms A3G | ARCD | ARP-9 | ARP9 | bK150C2.7 | CEM-15 | CEM15 | dJ494G10.1 | MDS019
Gene Description APOBEC3G, apolipoprotein B mRNA editing enzyme catalytic subunit 3G, is a cytidine deaminase that induces C-to-U mutations in DNA, functioning in host defense against retroviruses and inhibits retrotransposons (PMID: 22001110). APOBEC3G expression correlates with poor prognosis in colon cancer patients with hepatic metastasis (PMID: 24753761), overexpression has been observed in uterine cervical intraepithelial neoplasia (PMID: 28590025), and overexpression in high-grade serous ovarian carcinoma has been associated with a favorable prognosis (PMID: 27016308).
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