Gene Detail

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Gene Symbol ROS1
Synonyms c-ros-1 | MCF3 | ROS
Gene Description ROS1, ROS proto-oncogene 1, receptor tyrosine kinase, is an orphan receptor tyrosine kinase that may activates multiple pathways involved in cell survival and transformation (PMID: 23719267, PMID: 32327173). ROS1 fusion proteins frequently lead to constitutive activation of Ros1 signaling and have been identified in glioblastoma, non-small cell lung cancer, cholangiocarcinoma, ovarian cancer, gastric adenocarcinoma, colorectal cancer, inflammatory myofibroblastic tumor, angiosarcoma, glioma, and epithelioid hemangioendothelioma (PMID: 23719267, PMID: 30262706, PMID: 30171048, PMID: 3004937), and ROS1 mutations are often associated with acquired resistance to inhibition (PMID: 31256210).

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Molecular Profile Protein Effect Treatment Approaches
ROS1 A1186D unknown
ROS1 A1924_I1934del unknown
ROS1 A1964T unknown
ROS1 A1998G unknown
ROS1 A2081T unknown
ROS1 A87T unknown
ROS1 A887V unknown
ROS1 act mut gain of function
ROS1 amp no effect
ROS1 C2060G unknown
ROS1 C72R unknown
ROS1 D1192V unknown
ROS1 D1776H unknown
ROS1 D2033N unknown
ROS1 D2058G unknown
ROS1 D2113G unknown
ROS1 D2113N unknown
ROS1 D2213N unknown
ROS1 D2247Y unknown
ROS1 D780Y unknown
ROS1 dec exp no effect
ROS1 del loss of function
ROS1 E1244* loss of function - predicted
ROS1 E1737* loss of function - predicted
ROS1 E1840* loss of function - predicted
ROS1 E1902K unknown
ROS1 E1935G unknown
ROS1 E1974K unknown
ROS1 E1990G unknown
ROS1 E2020K unknown
ROS1 E2131D unknown
ROS1 E2265D unknown
ROS1 E2308* unknown
ROS1 E2308K unknown
ROS1 E290* loss of function - predicted
ROS1 E341D unknown
ROS1 E539* loss of function - predicted
ROS1 E919K unknown
ROS1 F2004C unknown
ROS1 F2004I unknown
ROS1 F2004L unknown
ROS1 F2004V unknown
ROS1 F2075C unknown
ROS1 F2075V unknown
ROS1 F250L unknown
ROS1 F383S unknown
ROS1 F923I unknown
ROS1 fusion unknown ROS1 Inhibitor
ROS1 fusion ROS1 L1951R ROS1 L2026M
ROS1 fusion KIT D816G
ROS1 fusion ROS1 G2032R
ROS1 fusion ROS1 S1986F ROS1 L2000V
ROS1 G1027D unknown
ROS1 G1556R unknown
ROS1 G1915R unknown
ROS1 G1954R unknown
ROS1 G1971E unknown
ROS1 G2032K unknown
ROS1 G2032R unknown
ROS1 G2066C unknown
ROS1 G2101A unknown
ROS1 G2148V unknown
ROS1 G365A unknown
ROS1 G514fs loss of function - predicted
ROS1 G666S unknown
ROS1 I2239* loss of function - predicted
ROS1 I537M unknown
ROS1 inact mut loss of function
ROS1 K1163N unknown
ROS1 K1552T unknown
ROS1 K1887Q unknown
ROS1 K1980E unknown
ROS1 K2003I unknown
ROS1 K2099N unknown
ROS1 K2228Q unknown
ROS1 K298* loss of function - predicted
ROS1 L1947R unknown
ROS1 L1950F unknown
ROS1 L1951R unknown
ROS1 L1982F unknown
ROS1 L2000V unknown
ROS1 L2026M unknown
ROS1 rearrange ROS1 L2026M TP53 P278H
ROS1 L2028M unknown
ROS1 L2086F unknown
ROS1 L2086I unknown
ROS1 L2155S unknown
ROS1 L567V unknown
ROS1 M1805V unknown
ROS1 M2073T unknown
ROS1 M2128V unknown
ROS1 M2134I unknown
ROS1 mutant unknown
ROS1 N1534K unknown
ROS1 N1800T unknown
ROS1 N2240K unknown
ROS1 N790S unknown
ROS1 negative loss of function
ROS1 P1020fs loss of function - predicted
ROS1 P1020H unknown
ROS1 P1020S unknown
ROS1 P1440L unknown
ROS1 P1440S unknown
ROS1 P151S unknown
ROS1 P1539S unknown
ROS1 P1721T unknown
ROS1 P2130T unknown
ROS1 P671Q unknown
ROS1 positive unknown
ALK neg ROS1 pos
ROS1 Q1797H unknown
ROS1 Q1889P unknown
ROS1 Q2012K unknown
ROS1 Q617H unknown
ROS1 R118Q unknown
ROS1 R167Q unknown
ROS1 R2078W unknown
ROS1 R2083G unknown
ROS1 R2096L unknown
ROS1 R2096Q unknown
ROS1 R2096W unknown
ROS1 R2116K unknown
ROS1 R2205I unknown
ROS1 R245I unknown
ROS1 R304I unknown
ROS1 R360I unknown
ROS1 R380I unknown
ROS1 R77W unknown
ROS1 rearrange unknown ROS1 Inhibitor
ROS1 rearrange TP53 mut
ROS1 rearrange PIK3CA E545K
ROS1 rearrange ALK neg
ALK rearrange ROS1 rearrange
ROS1 - GOPC unknown
ROS1 S1109L unknown
ROS1 S1577Y unknown
ROS1 S1581F unknown
ROS1 S1626Vfs*7 loss of function - predicted
ROS1 S1986F unknown
ROS1 S1986T unknown
ROS1 S1986Y unknown
ROS1 S2229C unknown
ROS1 S32I unknown
ROS1 S653F unknown
ROS1 T145P unknown
ROS1 T2195S unknown
ROS1 T804N unknown
ROS1 V1729L unknown
ROS1 V1979A unknown
ROS1 V1979E unknown
ROS1 V2089M unknown
ROS1 V2098I unknown
ROS1 V768L unknown
ROS1 V785M unknown
ROS1 W1694* loss of function - predicted
ROS1 W1817* loss of function - predicted
ROS1 W21* loss of function - predicted
ROS1 wild-type no effect
ROS1 Y1700* loss of function - predicted
ROS1 Y1960H unknown
ROS1 Y382H unknown
ROS1 Y718* loss of function - predicted