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|Synonyms||p70 S6KA | p70(S6K)-alpha | p70-alpha | p70-S6K | PS6K | S6K | S6K-beta-1 | S6K1 | STK14A|
|Gene Description||RPS6KB1, ribosomal protein S6 kinase B, encodes S6K1, which is a serine/threonine kinase that acts downstream of mTORC1, and plays a role in several cellular processes including cell growth, cell survival, and cell metabolism (PMID: 22168436, PMID: 20932932). RPS6KB1 amplification and over expression, as a consequence of 17q23 amplification, has been demonstrated in breast cancer (PMID: 10922410, PMID: 18335499).|