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Gene Symbol RPS6KB1
Synonyms p70 S6KA | p70(S6K)-alpha | p70-alpha | p70-S6K | PS6K | S6K | S6K-beta-1 | S6K1 | STK14A
Gene Description RPS6KB1, ribosomal protein S6 kinase B1, encodes S6K1, which is a serine/threonine kinase that acts downstream of mTORC1, and plays a role in several cellular processes including cell growth, cell survival, and cell metabolism (PMID: 22168436, PMID: 20932932). RPS6KB1 amplification and overexpression, as a consequence of 17q23 amplification, has been demonstrated in breast cancer (PMID: 10922410, PMID: 18335499) and overexpression has been observed to be oncogenic in hepatocellular carcinoma (PMID: 32201535).
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