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Gene Symbol SERPINB4
Synonyms LEUPIN | PI11 | SCCA-2 | SCCA1 | SCCA2
Gene Description SERPINB4, serpin family B member 4, is a member of the ov-serpin family of serine/cysteine protease inhibitors (PMID: 27637160) and plays a role in cell growth and inhibition of the immune system (PMID: 29642409). SERPINB4 overexpression has been associated with various types of squamous cell carcinomas (PMID: 27637160, PMID: 29642409), and mutations may be predictive of response to immunotherapy in melanoma (PMID: 27668655).


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