Gene Detail

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Gene Symbol SHH
Synonyms HHG1 | HLP3 | HPE3 | MCOPCB5 | ShhNC | SMMCI | TPT | TPTPS
Gene Description SHH, sonic hedgehog signaling molecule, encodes for a signaling protein that plays a significant role in embryonic development, specifically, in midline tissue formation and organogenesis, and thus, participates in cell growth, differentiation, and survival (PMID: 18794343). Overexpression of SHH has been associated with multiple tumor types including triple negative breast cancer, pancreatic cancer, prostate cancer, and breast cancer (PMID: 26727947, PMID: 14520413, PMID: 15132968, PMID: 20180807, PMID: 32184660).


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