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Gene Symbol DEPTOR
Synonyms DEP.6 | DEPDC6
Gene Description DEPTOR, DEP domain containing MTOR-interacting protein, is an mTOR binding protein that negatively regulates signaling by mTORC1 and mTORC2 (PMID: 19446321, PMID: 29897294). Aberrant expression of Deptor has been observed in a variety of tumor types, but a recent meta-analysis shows Deptor expression does not correlate with prognosis (PMID: 30174446), however, it may mediate chemoresistance (PMID: 28267437).


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