Gene Detail


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Gene Symbol BMI1
Synonyms flvi-2/bmi-1 | FLVI2/BMI1 | PCGF4 | RNF51
Gene Description BMI1, BMI1 proto-oncogene, polycomb ring finger, is a member of the polycomb repressive complex 1 (PRC1), which binds to Ring1b to inhibit expression of PRC1 target genes and has a PRC1-independent role in AR regulation (PMID: 26448339, PMID: 29402932, PMID: 29337063). Overexpression of BMI1 has been observed in a number of solid tumor types, including prostate cancer (PMID: 29402932), tongue squamous cell carcinoma (PMID: 29607565), and colon cancer (PMID: 29337063).
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