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|Synonyms||4F2 | 4F2HC | 4T2HC | CD98 | CD98HC | MDU1 | NACAE|
|Gene Description||SLC3A2, solute carrier family 3 member 2, encodes the heavy chain of the heterodimeric protein, CD98, and is a transmembrane type II protein that plays a role in the regulation of integrins and the modulation of amino acid transport, thereby contributing to various cell signaling mechanisms (PMID: 15625115, PMID: 17597067). SLC3A2 overexpression has been observed in a variety of tumor types including renal cell cancer, triple-negative breast cancer, biliary tract cancer, head and neck squamous cell carcinoma, osteosarcoma, and non-small cell lung cancer (PMID: 19292886, PMID: 28350098), and a fusion with SLC3A2 and NRG1 has been identified in lung cancer (PMID: 29959202).|