Gene Detail

Gene Symbol SMARCB1
Synonyms BAF47 | CSS3 | hSNFS | INI1 | MRD15 | PPP1R144 | RDT | RTPS1 | Sfh1p | SNF5 | SNF5L1 | Snr1 | SWNTS1
Gene Description SMARCB1, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1, is a member of the SWI/SNF chromatin remodeling complex and regulates transcription of several genes involved in cell proliferation (PMID: 23095836). Smarcb1 inactivation through loss is characteristic of atypical teratoid/rhabdoid tumors (PMID: 23095836), schwannomas (PMID: 28368924, PMID: 28824165), and sinonasal carcinomas (PMID: 29797680).
Entrez Id 6598
Chromosome 22
Map Location 22q11
Canonical Transcript NM_003073

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Variant Impact Protein Effect Variant Description Associated with drug Resistance
E184D missense unknown SMARCB1 E184D lies within the HIV-1 integrase-binding region of the Smarcb1 protein (UniProt.org). E184D has not been characterized in the scientific literature and therefore, its effect on Smarcb1 protein function is unknown (PubMed, Mar 2018).
R374W missense unknown SMARCB1 R374W does not lie within any known functional domains of the Smarcb1 protein (UniProt.org). R374W has been identified in sequencing studies (PMID: 22895193), but has not been biochemically characterized and therefore, its effect on Smarcb1 protein function is unknown (PubMed, Mar 2018).
negative unknown unknown SMARCB1 negative indicates a lack of the SMARCB1 gene, mRNA, or protein.
T149K missense unknown SMARCB1 T149K does not lie within any known functional domains of the Smarcb1 protein (UniProt.org). T149K has not been characterized in the scientific literature and therefore, its effect on Smarcb1 protein function is unknown (PubMed, Mar 2018).
L142I missense unknown SMARCB1 L142I lies within the DNA binding region of the Smarcb1 protein (UniProt.org). L142I has been identified in sequencing studies (PMID: 26111976), but has not been biochemically characterized and therefore, its effect on Smarcb1 protein function is unknown (PubMed, Mar 2018).
K126N missense unknown SMARCB1 K126N lies within the DNA binding region of the Smarcb1 protein (UniProt.org). K126N has not been characterized in the scientific literature and therefore, its effect on Smarcb1 protein function is unknown (PubMed, Mar 2018).
amp none no effect SMARCB1 amplification indicates an increased number of copies of the SMARCB1 gene. However, the mechanism causing the increase is unspecified.
del deletion loss of function SMARCB1 del indicates a deletion of the SMARCB1 gene.
R261C missense unknown SMARCB1 R261C lies within repeat 2 of the Smarcb1 protein (UniProt.org). R261C has not been characterized in the scientific literature and therefore, its effect on Smarcb1 protein function is unknown (PubMed, Mar 2018).
Q368* nonsense unknown SMARCB1 Q368* results in a premature truncation of the Smarcb1 protein at amino acid 368 of 385 (UniProt.org). Q368* has been identified in sequencing studies (PMID: 26437031), but has not been biochemically characterized and therefore, its effect on Smarcb1 protein function is unknown (PubMed, Mar 2018).
Q18* nonsense loss of function - predicted SMARCB1 Q18* results in a premature truncation of the Smarcb1 protein at amino acid 18 of 385 (UniProt.org). Due to the loss of all known functional domains (UniProt.org), Q18* is predicted to lead to a loss of Smarcb1 protein function.
D159N missense unknown SMARCB1 D159N does not lie within any known functional domains of the Smarcb1 protein (UniProt.org). D159N has not been characterized in the scientific literature and therefore, its effect on Smarcb1 protein function is unknown (PubMed, Mar 2018).
R201Q missense unknown SMARCB1 R201Q lies within repeat 1 of the Smarcb1 protein (UniProt.org). R201Q has been identified in sequencing studies (PMID: 27284491), but has not been biochemically characterized in the scientific literature and therefore, its effect on Smarcb1 protein function is unknown (PubMed, Mar 2018).
positive unknown unknown SMARCB1 positive indicates the presence of the SMARCB1 gene, mRNA, and/or protein.
K364del missense unknown SMARCB1 K364del results in the deletion of one amino acid of the Smarcb1 protein at amino acid 364 (UniProt.org). K364del has not been characterized and therefore, its effect on Smarcb1 protein function is unknown (PubMed, Feb 2018).
F307V missense unknown SMARCB1 F307V lies within repeat 2 of the Smarcb1 protein (UniProt.org). F307V has not been characterized in the scientific literature and therefore, its effect on Smarcb1 protein function is unknown (PubMed, Mar 2018).
D104N missense unknown SMARCB1 D104N lies within the DNA binding region of the Smarcb1 protein (UniProt.org). D104N has been identified in sequencing studies (PMID: 22810696), but has not been biochemically characterized and therefore, its effect on Smarcb1 protein function is unknown (PubMed, Mar 2018).
P351S missense unknown SMARCB1 P351S does not lie within any known functional domains of the Smarcb1 protein (UniProt.org). P351S has been identified in sequencing studies (PMID: 21720365), but has not been biochemically characterized and therefore, its effect on Smarcb1 protein function is unknown (PubMed, Mar 2018).
T72Qfs*13 frameshift loss of function - predicted SMARCB1 T72Qfs*13 indicates a shift in the reading frame starting at amino acid 72 and terminating 13 residues downstream causing a premature truncation of the 385 amino acid Smarcb1 protein (UniProt.org). Due to the loss of all known functional domains (UniProt.org), T72Qfs*13 is predicted to lead to a loss of Smarcb1 protein function.
D22G missense unknown SMARCB1 D22G lies within the DNA binding region of the Smarcb1 protein (UniProt.org). D22G has not been characterized in the scientific literature and therefore, its effect on Smarcb1 protein function is unknown (PubMed, Mar 2018).
loss unknown loss of function SMARCB1 loss indicates loss of the SMARCB1 gene, mRNA or protein.
D259N missense unknown SMARCB1 D259N lies within repeat 2 of the Smarcb1 protein (UniProt.org). D259N has not been characterized in the scientific literature and therefore, its effect on Smarcb1 protein function is unknown (PubMed, Mar 2018).
E31K missense unknown SMARCB1 E31K lies within the DNA binding region of the Smarcb1 protein (UniProt.org). E31K has not been characterized in the scientific literature and therefore, its effect on Smarcb1 protein function is unknown (PubMed, Mar 2018).
S274F missense unknown SMARCB1 S274F lies within repeat 2 of the Smarcb1 protein (UniProt.org). S274F has not been characterized in the scientific literature and therefore, its effect on Smarcb1 protein function is unknown (PubMed, Mar 2018).
R377H missense unknown SMARCB1 R377H does not lie within any known functional domains of the Smarcb1 protein (UniProt.org). R377H has been identified in the scientific literature (PMID: 23334667, PMID: 11161377, PMID: 24993163), but has not been biochemically characterized and therefore, its effect on Smarcb1 protein function is unknown (PubMed, Mar 2018).
inact mut unknown loss of function SMARCB1 inact mut indicates that this variant results in a loss of function of the Smarcb1 protein. However, the specific amino acid change has not been identified.
S252I missense unknown SMARCB1 S252I lies within the tandem repeat region of the Smarcb1 protein (UniProt.org). S252I has not been characterized in the scientific literature and therefore, its effect on Smarcb1 protein function is unknown (PubMed, Mar 2018).
D202E missense unknown SMARCB1 D202E lies within repeat 1 and the HIV-1 integrase and MYC-binding regions of the Smarcb1 protein (UniProt.org). D202E has not been characterized in the scientific literature and therefore, its effect on Smarcb1 protein function is unknown (PubMed, Mar 2018).
P133T missense unknown SMARCB1 P133T lies within the DNA binding region of the Smarcb1 protein (UniProt.org). P133T has not been characterized in the scientific literature and therefore, its effect on Smarcb1 protein function is unknown (PubMed, Mar 2018).
R374Q missense unknown SMARCB1 R374Q does not lie within any known functional domains of the Smarcb1 protein (UniProt.org). R374Q has been identified in the scientific literature (PMID: 26285240, PMID: 23334667), but has not been biochemically characterized and therefore, its effect on Smarcb1 protein function is unknown (PubMed, Mar 2018).
Y47S missense unknown SMARCB1 Y47S lies within the DNA binding region of the Smarcb1 protein (UniProt.org). Y47S has not been characterized and therefore, its effect on Smarcb1 protein function is unknown (PubMed, Feb 2018).
G80R missense unknown SMARCB1 G80R lies within the DNA binding region of the Smarcb1 protein (UniProt.org). G80R has not been characterized in the scientific literature and therefore, its effect on Smarcb1 protein function is unknown (PubMed, Mar 2018).
R190L missense unknown SMARCB1 R190L lies within repeat 1 of the Smarcb1 protein (UniProt.org). R190L has not been characterized in the scientific literature and therefore, its effect on Smarcb1 protein function is unknown (PubMed, Mar 2018).
Y326* nonsense unknown SMARCB1 Y326* results in a premature truncation of the Smarcb1 protein at amino acid 326 of 385 (UniProt.org). Y326* has not been characterized and therefore, its effect on Smarcb1 protein function is unknown (PubMed, Feb 2018).
R53Q missense unknown SMARCB1 R53Q lies within the DNA binding region of the Smarcb1 protein (UniProt.org). R53Q has been identified in the scientific literature (PMID: 28692054), but has not been biochemically characterized and therefore, its effect on Smarcb1 protein function is unknown (PubMed, Mar 2018).
P230Q missense unknown SMARCB1 P230Q lies in repeat 1 of the Smarcb1 (UniProt.org). P230Q has not been characterized in the scientific literature and therefore, its effect on Smarcb1 protein function is unknown (PubMed, Mar 2018).
S247C missense unknown SMARCB1 S247C lies within the tandem repeat region of the Smarcb1 protein (UniProt.org). S247C has not been characterized in the scientific literature and therefore, its effect on Smarcb1 protein function is unknown (PubMed, Mar 2018).
T381M missense unknown SMARCB1 T381M does not lie within any known functional domains of the Smarcb1 protein (UniProt.org). T381M has not been characterized in the scientific literature and therefore, its effect on Smarcb1 protein function is unknown (PubMed, Feb 2018).
K363N missense unknown SMARCB1 K363N does not lie within any known functional domains of the Smarcb1 protein (UniProt.org). K363N has been identified in sequencing studies (PMID: 26633542), but has not been biochemically characterized and therefore, its effect on Smarcb1 protein function is unknown (PubMed, Mar 2018).
T118Pfs*25 frameshift loss of function - predicted SMARCB1 T118Pfs*25 indicates a shift in the reading frame starting at amino acid 118 and terminating 25 residues downstream causing a premature truncation of the 385 amino acid Smarcb1 protein (UniProt.org). Due to the disruption of the DNA binding region and all other known functional domains (UniProt.org), T118Pfs*25 is predicted to lead to a loss of Smarcb1 protein function.
wild-type none no effect Wild-type SMARCB1 indicates that no mutation has been detected within the SMARCB1 gene.
A339V missense unknown SMARCB1 A339V does not lie within any known functional domains of the Smarcb1 protein (UniProt.org). A339V has not been characterized in the scientific literature and therefore, its effect on Smarcb1 protein function is unknown (PubMed, Mar 2018).
P188L missense unknown SMARCB1 P188L lies within repeat 1 of the Smarcb1 protein (UniProt.org). P188L has been identified in sequencing studies (PMID: 25769001), but has not been biochemically characterized and therefore, its effect on Smarcb1 protein function is unknown (PubMed, Mar 2018).
Q243* nonsense unknown SMARCB1 Q243* results in a premature truncation of the Smarcb1 protein at amino acid 243 of 385 (UniProt.org). Q243* has been identified in sequencing studies (PMID: 22895193), but has not been biochemically characterized and therefore, its effect on Smarcb1 protein function is unknown (PubMed, Mar 2018).
S94L missense unknown SMARCB1 S94L lies within the DNA binding region of the Smarcb1 protein (UniProt.org). S94L has not been characterized in the scientific literature and therefore, its effect on Smarcb1 protein function is unknown (PubMed, Mar 2018).
A312T missense unknown SMARCB1 A312T lies within repeat 2 of the Smarcb1 protein (UniProt.org). A312T has been identified in sequencing studies (PMID: 22895193), but has not been biochemically characterized and therefore, its effect on Smarcb1 protein function is unknown (PubMed, Mar 2018).
R377C missense unknown SMARCB1 R377C does not lie within any known functional domains of the Smarcb1 protein (UniProt.org). R377C has been identified in sequencing studies (PMID: 24670920), but has not been biochemically characterized in the scientific literature and therefore, its effect on Smarcb1 protein function is unknown (PubMed, Mar 2018).
R53* nonsense loss of function - predicted SMARCB1 R53* results in a premature truncation of the Smarcb1 protein at amino acid 53 of 385 (UniProt.org). Due to the loss of all known functional domains (UniProt.org), R53* is predicted to lead to a loss of Smarcb1 protein function.
T232M missense unknown SMARCB1 T232M lies within repeat 1 and the HIV-1 integrase and MYC-binding regions regions of the of the Smarcb1 protein (UniProt.org). T232M has not been characterized in the scientific literature and therefore, its effect on Smarcb1 protein function is unknown (PubMed, Feb 2018).
V262I missense unknown SMARCB1 V262I lies within repeat 2 and the HIV-1 integrase and MYC-binding regions of the Smarcb1 protein (UniProt.org). V262I has not been characterized and therefore, its effect on Smarcb1 protein function is unknown (PubMed, Feb 2018).
mutant unknown unknown SMARCB1 mutant indicates an unspecified mutation in the SMARCB1 gene.
Q368R missense unknown SMARCB1 Q368R does not lie within any known functional domains of the Smarcb1 protein (UniProt.org). Q368R has been identified in sequencing studies (PMID: 21720365), but has not been biochemically characterized and therefore, its effect on Smarcb1 protein function is unknown (PubMed, Mar 2018).
H79Q missense unknown SMARCB1 H79Q lies within the DNA binding region of the Smarcb1 protein (UniProt.org). H79Q has not been characterized in the scientific literature and therefore, its effect on Smarcb1 protein function is unknown (PubMed, Mar 2018).
N207S missense unknown SMARCB1 N207S lies within repeat 1 of the Smarcb1 protein (UniProt.org). N207S has not been characterized in the scientific literature and therefore, its effect on Smarcb1 protein function is unknown (PubMed, Mar 2018).
E31V missense loss of function - predicted SMARCB1 E31V does not lie within any known functional domains of the Smarcb1 protein (UniProt.org). E31V has been reported to alter a donor splice site and consequently disrupt Smarcb1 mRNA expression in a family with a history of multiple schwannomas and meningiomas (PMID: 19582488).
R155H missense unknown SMARCB1 R155H lies within the DNA binding region of the Smarcb1 protein (UniProt.org). R155H has not been characterized in the scientific literature and therefore, its effect on Smarcb1 protein function is unknown (PubMed, Mar 2018).
R370S missense unknown SMARCB1 R370S does not lie within any known functional domains of the Smarcb1 protein (UniProt.org). R370S has not been characterized in the scientific literature and therefore, its effect on Smarcb1 protein function is unknown (PubMed, Mar 2018).
T72Nfs*4 frameshift loss of function - predicted SMARCB1 T72Nfs*4 indicates a shift in the reading frame starting at amino acid 72 and terminating 4 residues downstream causing a premature truncation of the 385 amino acid Smarcb1 protein (UniProt.org). Due to the loss of all known functional domains (UniProt.org), T72Nfs*4 is predicted to lead to a loss of Smarcb1 protein function.
F279C missense unknown SMARCB1 F279C lies within repeat 2 of the Smarcb1 protein (UniProt.org). F279C has not been characterized in the scientific literature and therefore, its effect on Smarcb1 protein function is unknown (PubMed, Mar 2018).
K8N missense unknown SMARCB1 K8N lies within the DNA binding region of the Smarcb1 protein (UniProt.org). K8N has not been characterized in the scientific literature and therefore, its effect on Smarcb1 protein function is unknown (PubMed, Mar 2018).
D169H missense unknown SMARCB1 D169H does not lie within any known functional domains of the Smarcb1 protein (UniProt.org). D169H has not been characterized in the scientific literature and therefore, its effect on Smarcb1 protein function is unknown (PubMed, Mar 2018). 
Molecular Profile Protein Effect Treatment Approaches
SMARCB1 E184D unknown
SMARCB1 R374W unknown
CDKN2A over exp SMARCB1 negative
SMARCB1 negative unknown
SMARCB1 T149K unknown
SMARCB1 L142I unknown
SMARCB1 K126N unknown
SMARCB1 amp no effect
SMARCB1 del loss of function CDK Inhibitor (Pan) CDK4/6 Inhibitor EZH2 inhibitor Fenretinide MRX34
SMARCB1 R261C unknown
SMARCB1 Q368* unknown
SMARCB1 Q18* loss of function - predicted CDK Inhibitor (Pan) CDK4/6 Inhibitor EZH2 inhibitor Fenretinide MRX34
SMARCB1 D159N unknown
SMARCB1 R201Q unknown
SMARCB1 positive unknown
SMARCB1 K364del unknown
SMARCB1 F307V unknown
SMARCB1 D104N unknown
SMARCB1 P351S unknown
SMARCB1 T72Qfs*13 loss of function - predicted CDK Inhibitor (Pan) CDK4/6 Inhibitor EZH2 inhibitor Fenretinide MRX34
SMARCB1 D22G unknown
SMARCB1 loss loss of function CDK Inhibitor (Pan) CDK4/6 Inhibitor EZH2 inhibitor Fenretinide MRX34
SMARCB1 D259N unknown
SMARCB1 E31K unknown
SMARCB1 S274F unknown
SMARCB1 R377H unknown
EZH2 Y111D SMARCB1 inact mut
SMARCB1 inact mut loss of function
SMARCB1 S252I unknown
SMARCB1 D202E unknown
SMARCB1 P133T unknown
SMARCB1 R374Q unknown
SMARCB1 Y47S unknown
SMARCB1 G80R unknown
SMARCB1 R190L unknown
SMARCB1 Y326* unknown
SMARCB1 R53Q unknown
SMARCB1 P230Q unknown
SMARCB1 S247C unknown
SMARCB1 T381M unknown
SMARCB1 K363N unknown
SMARCB1 T118Pfs*25 loss of function - predicted CDK Inhibitor (Pan) CDK4/6 Inhibitor EZH2 inhibitor Fenretinide MRX34
SMARCB1 wild-type no effect
SMARCB1 A339V unknown
SMARCB1 P188L unknown
SMARCB1 Q243* unknown
SMARCB1 S94L unknown
SMARCB1 A312T unknown
SMARCB1 R377C unknown
SMARCB1 R53* loss of function - predicted CDK Inhibitor (Pan) CDK4/6 Inhibitor EZH2 inhibitor Fenretinide MRX34
SMARCB1 T232M unknown
SMARCB1 V262I unknown
EZH2 Y111D SMARCB1 mut
SMARCB1 mut unknown
SMARCB1 Q368R unknown
SMARCB1 H79Q unknown
SMARCB1 N207S unknown
SMARCB1 E31V loss of function - predicted CDK Inhibitor (Pan) CDK4/6 Inhibitor EZH2 inhibitor Fenretinide MRX34
SMARCB1 R155H unknown
SMARCB1 R370S unknown
SMARCB1 T72Nfs*4 loss of function - predicted CDK Inhibitor (Pan) CDK4/6 Inhibitor EZH2 inhibitor Fenretinide MRX34
SMARCB1 F279C unknown
SMARCB1 K8N unknown
SMARCB1 D169H unknown
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
CDKN2A over exp SMARCB1 negative rhabdoid cancer decreased response Palbociclib Preclinical Actionable In a preclinical study, CDKN2A (p16) over expression was associated with decreased sensitivity to Ibrance (palbociclib) in a SMARCB1-negative malignant rhabdoid tumor cell line in culture (PMID: 21871868). 21871868
SMARCB1 negative rhabdoid cancer sensitive Palbociclib Preclinical Actionable In a preclinical study, Ibrance (palbociclib) inhibited growth of SMARCB1-negative malignant rhabdoid tumor cell lines in culture, and sensitivity was associated with low levels of p16 expression (PMID: 21871868). 21871868
SMARCB1 negative epithelioid sarcoma predicted - sensitive Tazemetostat Phase I Actionable In a Phase I trial, Tazemetostat (EPZ-6438) was well-tolerated and demonstrated anti-tumor activity in pediatric patients with SMARCB1 (INI)-deficient tumors, including complete or partial responses in patients with epithelioid sarcoma (n=1), chordoma (n=2), and atypical teratoid rhaboid tumor (n=1) (AACR-NCI-EORTC Int Conference on Molecular Targets and Cancer Therapeutics 2017, A175; NCT02601937). detail...
SMARCB1 negative rhabdoid cancer sensitive Fenretinide + Vorinostat Preclinical Actionable In a preclinical study, the combination of Zolinza (vorinostat) and fenretinide induced apoptosis and inhibited growth of rhabdoid tumor cell lines in culture (PMID: 23764045). 23764045
SMARCB1 negative rhabdoid cancer sensitive Alvocidib Preclinical - Cell line xenograft Actionable In a preclinical study, Alvocidib (flavopiridol) induced cell-cycle arrest and inhibited growth of human rhabdoid tumor cell lines with SMARCB1 biallelic deficiency in culture and inhibted tumor growth in SMARCB1-deficient cell line xenograft models (PMID: 18223228). 18223228
SMARCB1 negative atypical teratoid rhabdoid tumor predicted - sensitive Tazemetostat Phase I Actionable In a Phase I trial, Tazemetostat (EPZ-6438) was well-tolerated and demonstrated anti-tumor activity in pediatric patients with SMARCB1 (INI)-deficient tumors, including complete or partial responses in patients with epithelioid sarcoma (n=1), chordoma (n=2), and atypical teratoid rhaboid tumor (n=1) (AACR-NCI-EORTC Int Conference on Molecular Targets and Cancer Therapeutics 2017, A175; NCT02601937). detail...
SMARCB1 negative atypical teratoid rhabdoid tumor sensitive DZNeP + radiotherapy Preclinical Actionable In a preclinical study, DZNep increased radiosensitivity in SMARCB1-negative atypical teratoid rhabdoid tumor cell lines in culture (PMID: 23190500). 23190500
SMARCB1 negative chordoma predicted - sensitive Tazemetostat Phase I Actionable In a Phase I trial, Tazemetostat (EPZ-6438) was well-tolerated and demonstrated anti-tumor activity in pediatric patients with SMARCB1 (INI)-deficient tumors, including complete or partial responses in patients with epithelioid sarcoma (n=1), chordoma (n=2), and atypical teratoid rhaboid tumor (n=1) (AACR-NCI-EORTC Int Conference on Molecular Targets and Cancer Therapeutics 2017, A175; NCT02601937). detail...
SMARCB1 negative atypical teratoid rhabdoid tumor sensitive DZNeP Preclinical Actionable In a preclinical study, DZNep induced apoptosis and cell-cycle arrest and inhibited growth of SMARCB1-negative atypical teratoid rhabdoid tumor cell lines in culture (PMID: 23190500). 23190500
SMARCB1 del epithelioid sarcoma not applicable N/A Guideline Diagnostic SMARCB1 deletion aids the diagnosis of epithelioid sarcoma (NCCN.org). detail...
SMARCB1 loss rhabdoid cancer sensitive Tazemetostat Preclinical - Cell line xenograft Actionable In a preclinical study, Tazemetostat (EPZ-6438) inhibited growth of SMARCB1-deficient malignant rhabdoid tumor cell lines in culture, and inhibited H3K27 trimethylation and induced tumor regression in a SMARCB1-deleted human malignant rhabdoid tumor cell line xenograft model (PMID: 23620515). 23620515
SMARCB1 loss atypical teratoid rhabdoid tumor sensitive CFI-400945 Preclinical - Cell culture Actionable In a preclinical study, CFI-400945 inhibited proliferation and decreased survival and migration of SMARCB1-deficient atypical teratoid rhabdoid tumor cells in culture (PMID: 28398638). 28398638
EZH2 Y111D SMARCB1 inact mut rhabdoid cancer resistant Tazemetostat Preclinical - Cell culture Actionable In a preclinical study, over expression of EZH2 Y111D in rhabdoid tumor cells harboring an SMARCB1 inactivating mutation resulted in resistance to Tazemetostat (EPZ-6438) treatment in culture (PMID: 26360609). 26360609
SMARCB1 inact mut epithelioid sarcoma not applicable N/A Guideline Diagnostic SMARCB1 inactivating mutations aid the diagnosis of epithelioid sarcoma (NCCN.org). detail...