Gene Detail


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Gene Symbol SMARCC1
Synonyms BAF155 | CRACC1 | HYC5 | Rsc8 | SRG3 | SWI3
Gene Description SMARCC1, SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1, encodes a key component of the SWI/SNF chromatin remodeling complex (PMID: 31427792, PMID: 22139574) that regulates transcription activation (PMID: 11018012), cell survival (PMID: 22139574), and embryonic stem cell differentiation (PMID: 19785031). Increased Smarcc1 expression has been observed in colorectal cancer (PMID: 19156145) and prostate cancer (PMID: 18581278), while loss of Smarcc1 expression has been identified in urothelial cancer (PMID: 27339451), epithelioid sarcoma (PMID: 29309303), and renal cell carcinoma (PMID: 29689242).
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