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Gene Symbol STAT3
Gene Description STAT3, signal transducer and activator of transcription 3, is one of seven members of the STAT family of transcription factors that mediates IL6 cytokine signaling and plays a role in inflammation and the anti-tumor response (PMID: 32365499, PMID: 32331320, PMID: 32278856). STAT3 has been shown to demonstrate both oncogenic and tumor suppressor activity, in a context dependent manner, in several solid tumors, including lung, brain, colorectal, pancreatic, thyroid, and prostate cancers (PMID: 32365499) and is often constitutively activated in cancer (PMID: 32278856).
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