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Gene Symbol STAT3
Synonyms ADMIO | ADMIO1 | APRF | HIES
Gene Description STAT3, signal transducer and activator of transcription 3, is one of seven members of the STAT family of transcription factors that mediates IL6 cytokine signaling and plays a role in inflammation and the anti-tumor response (PMID: 32365499, PMID: 32331320, PMID: 32278856). STAT3 has been shown to demonstrate both oncogenic and tumor suppressor activity, in a context dependent manner, in several solid tumors, including lung, brain, colorectal, pancreatic, thyroid, and prostate cancers (PMID: 32365499) and is often constitutively activated in cancer (PMID: 32278856).


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