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Gene Symbol STK3
Synonyms KRS1 | MST2
Gene Description STK3, serine/threonine kinase 3, is a member of the mammalian sterile twenty (MST) kinase family (PMID: 30882881) and is activated by caspases to promote DNA fragmentation during apoptosis (PMID: 29876001) and may play a role in the innate immune response (PMID: 28757478). Stk3 functions as a putative tumor suppressor within the Hippo pathway through YAP1 to regulate cell proliferation (PMID: 15994916, PMID: 24336504, PMID: 29876001), and may also promote tumorigenesis in other tumor types (PMID: 29876001).


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