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Gene Symbol STK11
Synonyms hLKB1 | LKB1 | PJS
Gene Description STK11, serine/threonine kinase 11, is a tumor suppressor (PMID: 30562755) involved in cell metabolism, growth, polarity, and tumor suppression through the regulation of AMPK family members (PMID: 26398719). STK11 germline mutations are common in Peutz-Jeghers syndrome and somatic STK11 mutations have been identified in melanoma, lung, pancreatic, cervical, and endometrial cancers (PMID: 26877140, PMID: 29191602) and are often associated with resistance to immune checkpoint blockcade (PMID: 30626603).
ACMG Incidental List v2.0:
Yes, Peutz-Jeghers syndrome (PMID: 27854360)

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Molecular Profile Protein Effect Treatment Approaches
STK11 A205T loss of function mTOR Inhibitor mTORC1 Inhibitor
STK11 A218Sfs*42 loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 A241P unknown
STK11 A377P unknown
STK11 A389T unknown
STK11 amp no effect
ROS1 fusion ERBB2 amp NOTCH1 amp SRC amp STK11 amp
STK11 C132F unknown
STK11 C278fs loss of function - predicted
STK11 D176A unknown
STK11 D176H unknown
STK11 D176N loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 D176Y loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 D194E loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 D194E STK11 loss
STK11 D194H unknown
STK11 D194N unknown
STK11 D194Y loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 D207Gfs*59 loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 D237N unknown
STK11 D237Y unknown
STK11 D277Y loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 D30N loss of function
STK11 D343N unknown
STK11 D350E unknown
STK11 D355N unknown
STK11 D358N unknown
STK11 D359Y unknown
STK11 D53Tfs*11 loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 dec exp no effect
STK11 E120* loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 E121* loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 E138* loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 E165* loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 E199* loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 E199K loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 E199Q no effect - predicted
STK11 E223* loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 E223V loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 E317* unknown
STK11 E317K unknown
STK11 E33* loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 E357K unknown
STK11 E57fs loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 E57Sfs*107 loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 E65* loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 E70* loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 E98_G155del loss of function
STK11 F157S loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 F298L unknown
STK11 F309* loss of function
STK11 F354L loss of function mTOR Inhibitor mTORC1 Inhibitor
STK11 G163D loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 G171S loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 G196V unknown
STK11 G242V unknown
STK11 G242W unknown
STK11 G251C unknown
STK11 G251F unknown
STK11 G251V unknown
STK11 G288S no effect - predicted
STK11 G56Tfs*4 loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 G56V unknown
STK11 G56W unknown
STK11 G61Afs*3 loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 H107L unknown
STK11 H168R unknown
STK11 H174D unknown
STK11 H174R loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 H174Y unknown
STK11 I111N unknown
STK11 I177N loss of function mTOR Inhibitor mTORC1 Inhibitor
STK11 I177T unknown
STK11 I248T unknown
STK11 I303N unknown
STK11 I303S unknown
STK11 I35Lfs*127 loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 inact mut loss of function mTOR Inhibitor mTORC1 Inhibitor
STK11 K175_D176del loss of function
STK11 K41* loss of function - predicted
STK11 K44* loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 K48fs loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 K62* loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 K62Sfs*100 loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 K78A loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 K78E unknown
STK11 K78I loss of function mTOR Inhibitor mTORC1 Inhibitor
STK11 K78N unknown
STK11 K84* loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 L160P unknown
STK11 L182P loss of function - predicted
STK11 L183V unknown
STK11 L195M unknown
STK11 L245F unknown
STK11 L245R loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 L263fs loss of function
STK11 L282Afs*3 loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 L285Lfs*2 loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 L285Q loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 L290P loss of function
STK11 L67P loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 loss loss of function mTOR Inhibitor mTORC1 Inhibitor
ERBB2 act mut STK11 loss
STK11 M136R loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 mutant unknown
STK11 N181E loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 N181I unknown
STK11 N181Y unknown
STK11 P179Q unknown
STK11 P179R unknown
STK11 P179S unknown
STK11 P221L unknown
STK11 P281fs loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 P281L loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 P281Pfs*4 loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 P281Rfs*6 loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 P294L unknown
STK11 P314H unknown
STK11 P321Hfs*38 unknown
STK11 P369S unknown
STK11 Q100* loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 Q123* loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 Q123R no effect
STK11 Q137* loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 Q159* loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 Q170* loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 Q170P loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 Q214* loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 Q220* loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 Q302* loss of function - predicted
STK11 Q364K unknown
STK11 Q37* loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 Q37L unknown
STK11 R297S unknown
STK11 R304G unknown
STK11 R304P no effect - predicted
STK11 R304W loss of function mTOR Inhibitor mTORC1 Inhibitor
STK11 R310P unknown
STK11 R333C unknown
STK11 R409W no effect - predicted
STK11 R86G no effect
STK11 S193F unknown
STK11 S19P unknown
STK11 S19W no effect - predicted
STK11 S216F loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 S232P no effect
STK11 S240* loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 S419F unknown
STK11 T230P no effect
STK11 T250P loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 V236A unknown
STK11 V320fs unknown
STK11 V66M no effect
STK11 W239C unknown
STK11 W308* loss of function - predicted
STK11 W308C loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 W332* unknown
STK11 wild-type no effect
STK11 Y118* loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 Y272H loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 Y36D unknown
STK11 Y49D unknown
STK11 Y60* loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor